Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 7/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RHEB | Q15382 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2547093 | 0.86 | REN (0.52) | MAPTHPGDMAPK1L3MBTL1REN | |
| SCHEMBL661830 | 0.85 | MAPT (0.48) | MAPTHPGDMAPK1L3MBTL1KDM4E | |
| SCHEMBL662629 | 0.85 | MAPT (0.43) | MAPTHPGDMAPK1L3MBTL1KDM4E | |
| SCHEMBL662025 | 0.84 | MAPT (0.47) | MAPTHPGDMAPK1L3MBTL1KDM4E | |
| SCHEMBL8407758 | 0.81 | MAPT (0.42) | MAPTHPGDMAPK1L3MBTL1TDP1 | |
| SCHEMBL5069445 | 0.81 | MAPT (0.47) | MAPTHPGDMAPK1L3MBTL1KDM4E | |
| SCHEMBL662083 | 0.80 | MAPT (0.43) | MAPTHPGDMAPK1L3MBTL1KDM4E | |
| SCHEMBL660641 | 0.77 | MAPT (0.51) | MAPTHPGDMAPK1L3MBTL1KDM4E | |
| SCHEMBL2376058 | 0.75 | MAPT (0.54) | MAPTHPGDMAPK1L3MBTL1KDM4E | |
| SCHEMBL8409247 | 0.74 | MAOB (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
| US-8063105-B2 | Renin inhibitors | MERCK CANADA INC. (CA) | 2011-11-22 | — | — | US | disclosed |
| US-20090281103-A1 | Renin Inhibitors | MERCK CANADA INC. (CA) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | MAPT 3436/4885HPGD 559/4885MAPK1 830/4885 |
| US-20090281103-A1 | Renin Inhibitors | REN, ACE, AGT | MAPT 3785/4885HPGD 523/4885MAPK1 497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.