Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HMGCR | P04035 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 2/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | SREBF2 | Q12772 | 2/20 | 0.33 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5072115 | 0.81 | ACSS2 (0.34) | ALDH1A1MAPTMTNR1AACSS2MAOA | |
| SCHEMBL19330160 | 0.79 | MEN1 (0.39) | ALDH1A1MAPTMTNR1AACSS2SMN1; SMN2 | |
| SCHEMBL19330347 | 0.79 | HPGD (0.34) | ALDH1A1MAPTMTNR1AACSS2HPGD | |
| SCHEMBL30701188 | 0.79 | MEN1 (0.39) | ALDH1A1MAPTMTNR1AACSS2SMN1; SMN2 | |
| SCHEMBL28118987 | 0.78 | KDM4E (0.39) | ALDH1A1MAPTMTNR1AMTNR1B | |
| SCHEMBL12093550 | 0.76 | SLC13A5 (0.51) | ADRA2AADRA2BADRA2CMAOASLC13A5 | |
| SCHEMBL28301401 | 0.75 | PPARA (0.43) | MTNR1AMTNR1BSLC13A5 | |
| SCHEMBL6645213 | 0.74 | HSD17B10 (0.41) | ALDH1A1MAPTMTNR1AHPGDSLC13A5 | |
| SCHEMBL5072695 | 0.74 | CYP3A4 (0.42) | ALDH1A1MAPTMTNR1AACSS2SMN1; SMN2 | |
| SCHEMBL24344519 | 0.72 | AURKA (0.38) | MTNR1AHPGDSMN1; SMN2NOS2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007386-A2 | CAMPTOTHECIN-ANALOG WITH A NOVEL, FLIPPED LACTONE-STABLE, E-RING AND METHODS FOR MAKING AND USING SAME | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007123995-A2 | CAMPTOTHECIN-ANALOG WITH A NOVEL, “FLIPPED” LACTONE-STABLE, E-RING AND METHODS FOR MAKING AND USING SAME | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2007-11-01 | — | — | WO | disclosed |
| EP-0035893-A2 | Herbicidal benzene- and pyridine-sulfonamide derivatives | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-09-16 | — | — | EP | disclosed |