Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 13/20 | 0.52 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.51 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 2/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.48 |
| ▸ | FLT1 | P17948 | 2/20 | 0.48 |
| ▸ | FLT4 | P35916 | 2/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377364 | 0.81 | PDE3B (0.61) | EGFRPDE3BPDE3APDE10AKDR | |
| SCHEMBL2925101 | 0.81 | PDE3B (0.61) | EGFRPDE3BPDE3APDE10AKDR | |
| SCHEMBL30288390 | 0.81 | PDPK1 (0.53) | PDGFRBPDGFRAPDPK1EGFRKIT | |
| SCHEMBL24444648 | 0.79 | PDGFRB (0.59) | PDGFRBPDGFRAPDPK1EGFRDNMT1 | |
| SCHEMBL7493881 | 0.78 | KDM4E (0.60) | PDPK1EGFRDNMT1EHMT2KDR | |
| SCHEMBL4299023 | 0.77 | PDGFRB (1.00) | PDGFRBPDGFRAPDE10A | |
| SCHEMBL30136402 | 0.76 | PDGFRB (0.56) | PDGFRBPDGFRADNMT1EHMT2MET | |
| Hydrochloric Acid SCHEMBL29357672 | 0.76 | PDGFRB (0.96) | PDGFRBPDGFRAPDE10A | |
| SCHEMBL8264497 | 0.75 | DNMT1 (0.48) | PDGFRBPDGFRAPDPK1EGFRDNMT1 | |
| SCHEMBL8306125 | 0.75 | EHMT2 (0.53) | PDGFRBPDGFRAPDPK1EGFREHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080268460-A1 | Assays to Identify Irreversibly Binding Inhibitors of Receptor Tyrosine Kinases | WYETH (US) | 2008-10-30 | — | — | US | disclosed |