Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 16/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 16/20 | 0.59 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.53 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.53 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.53 |
| ▸ | MLNR | O43193 | 1/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | NPY1R | P25929 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7625843 | 0.94 | ESR1 (0.58) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL6244353 | 0.72 | ESR1 (0.55) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL2475993 | 0.71 | ESR1 (0.75) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL6801025 | 0.71 | HRH3 (0.57) | ESR1ESR2HRH3 | |
| SCHEMBL6716259 | 0.71 | ESR1 (0.56) | ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL6249713 | 0.71 | ESR1 (0.56) | ESR1ESR2MLNRNR1I2NR3C1 | |
| Hydrochloric Acid SCHEMBL6246844 | 0.71 | ESR1 (0.56) | ESR1ESR2MLNRNR1I2NR3C1 | |
| Hydrochloric Acid SCHEMBL6245406 | 0.71 | ESR1 (0.56) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL13279099 | 0.70 | ESR1 (0.58) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL4688810 | 0.70 | MEN1 (0.62) | ESR1ESR2DRD2SLC6A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1932543-A2 | Combination therapy for osteoporosis consisting of an estrogen agonist/antagonist and a growth hormone secretagogue | Pfizer, Inc. (US) | 2008-06-18 | — | — | EP | disclosed |