Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 19/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 18/20 | 0.58 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.58 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.58 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5070352 | 0.94 | ESR1 (0.59) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL699174 | 0.77 | ESR1 (0.76) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL1359959 | 0.77 | ESR1 (0.76) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL2475993 | 0.76 | ESR1 (0.75) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL6244353 | 0.75 | ESR1 (0.55) | ESR1ESR2 | |
| SCHEMBL6801025 | 0.75 | HRH3 (0.57) | ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL6249713 | 0.75 | ESR1 (0.56) | ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL6246844 | 0.75 | ESR1 (0.56) | ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL6245406 | 0.75 | ESR1 (0.56) | ESR1ESR2 | |
| SCHEMBL6286153 | 0.73 | ESR1 (1.00) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1236475-A2 | Combination therapy for osteoporosis consisting of an estrogen agonist/antagonist and a growth hormone secretagogue | PFIZER INC. (US) | 2002-09-04 | — | — | EP | disclosed |