Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 18/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 18/20 | 0.55 |
| ▸ | MLNR | O43193 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | NPY1R | P25929 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6249713 | 0.99 | ESR1 (0.56) | ESR1ESR2MLNRNR1I2NR3C1 | |
| Hydrochloric Acid SCHEMBL6246844 | 0.99 | ESR1 (0.56) | ESR1ESR2MLNRNR1I2NR3C1 | |
| Hydrochloric Acid SCHEMBL6245406 | 0.99 | ESR1 (0.56) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL8103607 | 0.76 | ESR1 (0.64) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL7625843 | 0.75 | ESR1 (0.58) | ESR1ESR2 | |
| SCHEMBL6058992 | 0.75 | ESR1 (0.61) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL6058984 | 0.75 | ESR1 (0.61) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL6058988 | 0.75 | ESR1 (0.61) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL5070352 | 0.72 | ESR1 (0.59) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL6245868 | 0.71 | ESR1 (1.00) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1559707-A1 | SPIRO COMPOUNDS, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THE COMPOUNDS | Dainippon Pharmaceutical Co., Ltd. (JP) | 2005-08-03 | — | — | EP | claimed |
| US-20050256308-A1 | Spiro compounds, medicinal compositions containing the same and intermediates of the compounds | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2005-11-17 | — | — | US | disclosed |
| EP-1559707-A1 | SPIRO COMPOUNDS, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THE COMPOUNDS | Dainippon Pharmaceutical Co., Ltd. (JP) | 2005-08-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256308-A1 | Spiro compounds, medicinal compositions containing the same and intermediates of the compounds | ESRRA, ESR1, BRCA1 | ESR1 2/4885ESR2 4/4885MLNR 1097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.