Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MPI | P34949 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | FNTA | P49354 | 2/20 | 0.34 |
| ▸ | FNTB | P49356 | 2/20 | 0.34 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.34 |
| ▸ | HRH2 | P25021 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5140882 | 0.88 | ALDH1A1 (0.41) | ALDH1A1KDM4EPOLBKMT2AMAPT | |
| SCHEMBL5070139 | 0.84 | ALDH1A1 (0.35) | ALDH1A1KDM4EPOLBKMT2AMAPT | |
| SCHEMBL3191049 | 0.82 | ALDH1A1 (0.41) | ALDH1A1KDM4EPOLBKMT2AMAPT | |
| SCHEMBL4005590 | 0.81 | ALDH1A1 (0.45) | ALDH1A1KDM4EPOLBKMT2AMAPT | |
| SCHEMBL4005392 | 0.80 | ALDH1A1 (0.37) | ALDH1A1KDM4EPOLBKMT2AMAPT | |
| SCHEMBL5134714 | 0.79 | MEN1 (0.32) | KMT2AMEN1 | |
| SCHEMBL4007863 | 0.79 | GPR6 (0.38) | ALDH1A1KDM4EPOLBFNTAFNTB | |
| SCHEMBL5070391 | 0.77 | ALDH1A1 (0.41) | ALDH1A1KDM4EPOLBKMT2ATDP1 | |
| SCHEMBL5070149 | 0.76 | RORC (0.41) | — | |
| SCHEMBL4011678 | 0.75 | ALDH1A1 (0.40) | ALDH1A1KDM4EPOLBKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959960-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007070683-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |