Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5069516 | 0.76 | GRIN2B (0.50) | ALOX15NPC1SMYD3HTR2A | |
| SCHEMBL6973213 | 0.75 | PTPN1 (0.41) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| Bromide SCHEMBL3843849 | 0.75 | GRIN2B (0.49) | ALOX15NPC1SMYD3HTR2A | |
| SCHEMBL3846303 | 0.73 | MEN1 (0.39) | ALOX15NPC1LMNA | |
| SCHEMBL6535178 | 0.73 | MGAM (0.45) | NPC1LMNAHTT | |
| SCHEMBL7350316 | 0.73 | NPC1 (0.41) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| Bromide SCHEMBL3850340 | 0.72 | MGAM (0.44) | NPC1LMNAHTT | |
| SCHEMBL6535503 | 0.69 | CA12 (0.39) | ALOX15LMNAHTT | |
| SCHEMBL8546122 | 0.69 | LMNA (0.37) | ALOX15LMNA | |
| SCHEMBL1820216 | 0.69 | ALDH1A1 (0.46) | ALOX15NPC1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1128830-B1 | REVERSING ADVANCED GLYCOSYLATION CROSS-LINKS USING HETEROCYCLIC-SUBSTITUTED THIAZOLIUM SALTS | SYNVISTA THERAPEUTICS INC (US) | 2008-03-12 | — | — | EP | claimed |