SCHEMBL5070913

SCHEMBL5070913

COc1ccccc1Oc1nc(C(=O)NCC(=O)O)c(O)c2ccccc12.O=C(O)CNC(=O)c1nc(Oc2ccccc2F)c2ccccc2c1O

nearest known ligand 0.57

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
THRB P10828 16/20 0.57
THRA P10827 15/20 0.57
EGLN1 Q9GZT9 6/20 0.54
BBOX1 O75936 2/20 0.54
FTO Q9C0B1 2/20 0.54
SLC6A2 P23975 1/20 0.49
SLC6A3 Q01959 1/20 0.49
ASPH Q12797 1/20 0.49
KDM8 Q8N371 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL523556 0.95 EGLN1 (0.59) THRBTHRAEGLN1BBOX1FTO
SCHEMBL30274508 0.95 EGLN1 (0.59) THRBTHRAEGLN1BBOX1FTO
SCHEMBL522514 0.94 THRB (0.64) THRBTHRAEGLN1BBOX1FTO
SCHEMBL4758421 0.84 THRB (0.49) THRBTHRAEGLN1BBOX1FTO
SCHEMBL523057 0.83 THRB (0.73) THRBTHRAEGLN1BBOX1FTO
SCHEMBL5076083 0.83 THRB (0.59) THRBTHRAEGLN1BBOX1FTO
SCHEMBL522357 0.82 THRA (0.62) THRBTHRAEGLN1BBOX1FTO
SCHEMBL522444 0.82 THRA (0.72) THRBTHRAEGLN1BBOX1FTO
SCHEMBL523407 0.80 THRA (0.69) THRBTHRAEGLN1BBOX1FTO
SCHEMBL522529 0.79 THRB (0.71) THRBTHRAEGLN1BBOX1FTO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1893186-A2 IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT FIBROGEN, INC. (US) 2008-03-05 EP disclosed
WO-2006133391-A2 IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT FIBROGEN, INC. (US) 2006-12-14 WO disclosed