Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.59 |
| ▸ | SLC6A3 known ✓ | Q01959 | 3/20 | 0.59 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.59 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.59 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.50 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.50 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.50 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.50 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 8/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.59 |
| ▸ | RECQL | P46063 | 8/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.59 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1050423 | 0.98 | PLA2G1B (0.69) | PLA2G1BALOX15KDM4ERECQLTDP1 | |
| Hydrochloric Acid SCHEMBL28352199 | 0.96 | PLA2G1B (0.67) | PLA2G1BALOX15KDM4ERECQLTDP1 | |
| SCHEMBL17244102 | 0.83 | PLA2G1B (0.65) | PLA2G1BALOX15KDM4ERECQLTDP1 | |
| SCHEMBL11950426 | 0.82 | PLA2G1B (0.64) | PLA2G1BALOX15KDM4ERECQLTDP1 | |
| Bromide SCHEMBL8622617 | 0.82 | ALOX15 (0.68) | PLA2G1BALOX15KDM4ERECQLTDP1 | |
| SCHEMBL10893521 | 0.82 | PLA2G1B (0.48) | PLA2G1BALOX15KDM4ERECQLTDP1 | |
| SCHEMBL20417370 | 0.82 | PLA2G1B (0.64) | PLA2G1BALOX15KDM4ERECQLTDP1 | |
| SCHEMBL10804215 | 0.80 | PLA2G1B (0.47) | PLA2G1BALOX15KDM4ERECQLTDP1 | |
| SCHEMBL11274987 | 0.80 | PLA2G1B (0.47) | PLA2G1BALOX15KDM4ERECQLTDP1 | |
| SCHEMBL633687 | 0.79 | ALOX15 (0.70) | PLA2G1BALOX15KDM4ERECQLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273570-B2 | Inducing cell differentiation in embryonic cells; obtain cells, inoculate nutrient broths, propagate cells, recover cells | RIKEN (JP) | 2012-09-25 | — | — | US | disclosed |
| US-20080160617-A1 | AGENT FOR INDUCING EMBRYONIC STEM CELL TO ECTODERMAL CELL, METHOD FOR OBTAINING THE SAME, AND USE OF THE SAME | Sasai, Yoshiki (JP) | 2008-07-03 | — | — | US | disclosed |
| US-20060281179-A1 | Inducer for differentiation of embryo stem cells into ectodermal cells method of obtaining the same and use thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-12-14 | — | — | US | disclosed |
| EP-1452594-A1 | INDUCER FOR DIFFERENTIATION OF EMBRYO STEM CELLS INTO ECTODERMAL CELLS, METHOD OF OBTAINING THE SAME AND USE THEREOF | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2004-09-01 | — | — | EP | disclosed |
| EP-1302533-A1 | NOVEL METHOD OF INDUCING THE DIFFERENTIATION OF EMBRYONIC STEM CELLS INTO ECTODERMAL CELLS AND USE THEREOF | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2003-04-16 | — | — | EP | disclosed |
| US-20020151056-A1 | Novel differentiation inducing process of embryonic stem cell to ectodermal cell and its use | SASAI, YOSHIKI (JP) | 2002-10-17 | — | — | US | disclosed |