Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 10/20 | 0.41 |
| ▸ | CA1 | P00915 | 10/20 | 0.41 |
| ▸ | CA2 | P00918 | 10/20 | 0.41 |
| ▸ | CA9 | Q16790 | 5/20 | 0.41 |
| ▸ | CA4 | P22748 | 5/20 | 0.39 |
| ▸ | CA5A | P35218 | 5/20 | 0.39 |
| ▸ | CA7 | P43166 | 5/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14190563 | 0.82 | TSHR (0.49) | TSHRPTPN1LMNASMN1; SMN2THRB | |
| SCHEMBL6197791 | 0.81 | TSHR (0.48) | TSHRPTPN1LMNASMN1; SMN2THRB | |
| SCHEMBL6746384 | 0.78 | TSHR (0.49) | TSHRPTPN1LMNASMN1; SMN2THRB | |
| SCHEMBL14190561 | 0.77 | TSHR (0.51) | TSHRPTPN1LMNASMN1; SMN2THRB | |
| SCHEMBL10693255 | 0.73 | TSHR (0.59) | TSHRPTPN1LMNASMN1; SMN2THRB | |
| SCHEMBL14190569 | 0.69 | UMPS (0.54) | SMN1; SMN2 | |
| SCHEMBL4371658 | 0.68 | TSHR (0.70) | TSHRPTPN1THRBCA12CA1 | |
| SCHEMBL22928073 | 0.67 | TSHR (0.61) | TSHRPTPN1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL4965943 | 0.67 | TSHR (0.55) | TSHRPTPN1LMNASMN1; SMN2THRB | |
| SCHEMBL11167401 | 0.67 | THRB (0.64) | TSHRPTPN1LMNASMN1; SMN2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368437-B1 | Bicyclic heterocycles, processes for their preparation and their use as herbicides and pharmaceutical agents | BAYER CROPSCIENCE AG (DE) | 2008-05-06 | — | — | US | disclosed |
| US-7368437-B1 | Bicyclic heterocycles, processes for their preparation and their use as herbicides and pharmaceutical agents | BAYER CROPSCIENCE AG (DE) | 2008-05-06 | — | — | US | disclosed |
| US-7368437-B1 | Bicyclic heterocycles, processes for their preparation and their use as herbicides and pharmaceutical agents | BAYER CROPSCIENCE AG (DE) | 2008-05-06 | — | — | US | disclosed |
| EP-1165563-B1 | BICYCLIC HETEROCYCLES, METHOD FOR PRODUCING THEM AND THEIR USE AS HERBICIDES AND PHARMACEUTICAL AGENTS | BAYER CROPSCIENCE GMBH (DE) | 2005-03-02 | — | — | EP | disclosed |