Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 3/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 7/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 5/20 | 0.42 |
| ▸ | CDK1 | P06493 | 3/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.42 |
| ▸ | CDK4 | P11802 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | SMG1 | Q96Q15 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5068267 | 0.86 | IKBKB (0.44) | PIK3CGPIK3CASYKPIK3CBCDK2 | |
| SCHEMBL12423706 | 0.81 | PIK3CG (0.68) | PIK3CGPIK3CASYKPIK3CBCDK2 | |
| SCHEMBL5072180 | 0.80 | ABL1 (0.42) | PIK3CGSYKCDK2CDK1CCNB1 | |
| SCHEMBL5068257 | 0.80 | IKBKB (0.41) | PIK3CGABL1BCRSRCIKBKB | |
| SCHEMBL2200857 | 0.80 | SRC (0.47) | PIK3CGPIK3CASYKCDK2CDK1 | |
| SCHEMBL2194750 | 0.78 | PIK3CG (0.47) | PIK3CGPIK3CASYKPIK3CBCDK2 | |
| SCHEMBL2197880 | 0.76 | EPHB4 (0.48) | PIK3CGPIK3CASYKPIK3CBCDK2 | |
| SCHEMBL5070020 | 0.76 | CDK2 (0.44) | SYKCDK2CDK1CCNB1CDK4 | |
| SCHEMBL12509739 | 0.74 | IKBKB (0.42) | PIK3CGPIK3CASYKPIK3CBCDK2 | |
| SCHEMBL5070022 | 0.74 | AKT3 (0.55) | ABL1BCRSRCIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948647-A1 | PYRIMIDINYL-THIOPHENE KINASE MODULATORS | SGX Pharmaceuticals, Inc. (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007053776-A1 | PYRIMIDINYL-THIOPHENE KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2007-05-10 | — | — | WO | disclosed |