Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 3/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.68 |
| ▸ | CDK2 | P24941 | 8/20 | 0.63 |
| ▸ | SRC | P12931 | 5/20 | 0.63 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.63 |
| ▸ | SYK | P43405 | 4/20 | 0.63 |
| ▸ | ABL1 | P00519 | 2/20 | 0.58 |
| ▸ | BCR | P11274 | 2/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.55 |
| ▸ | CDK1 | P06493 | 2/20 | 0.53 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.53 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12423167 | 0.84 | PIK3CG (0.66) | PIK3CGPIK3CACDK2SRCZAP70 | |
| SCHEMBL2197763 | 0.84 | SRC (0.58) | PIK3CGPIK3CACDK2SRCZAP70 | |
| SCHEMBL2194750 | 0.83 | PIK3CG (0.47) | PIK3CGPIK3CACDK2SRCZAP70 | |
| SCHEMBL7470877 | 0.82 | CDK2 (0.70) | PIK3CGPIK3CACDK2SRCZAP70 | |
| SCHEMBL7473582 | 0.82 | CDK2 (0.65) | PIK3CGPIK3CACDK2SRCZAP70 | |
| SCHEMBL5072181 | 0.81 | PIK3CG (0.45) | PIK3CGPIK3CACDK2SRCZAP70 | |
| SCHEMBL2198846 | 0.79 | CDK2 (0.61) | PIK3CGPIK3CACDK2SRCZAP70 | |
| SCHEMBL7467324 | 0.78 | ABL1 (0.76) | PIK3CGPIK3CACDK2SRCZAP70 | |
| Hydrochloric Acid SCHEMBL2194727 | 0.78 | CDK2 (0.60) | PIK3CGPIK3CACDK2SRCZAP70 | |
| SCHEMBL14538029 | 0.78 | CDK2 (0.60) | PIK3CGPIK3CACDK2SRCZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977481-B2 | Pyrimidinyl-thiophene kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-7977481-B2 | Pyrimidinyl-thiophene kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-20100305128-A1 | Pyrimidinyl-Thiophene Kinase Modulators | ARNOLD WILLIAM D | 2010-12-02 | — | — | US | disclosed |
| US-20100305128-A1 | Pyrimidinyl-Thiophene Kinase Modulators | ARNOLD WILLIAM D | 2010-12-02 | — | — | US | disclosed |
| US-7803806-B2 | Pyrimidinyl-thiophene kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2010-09-28 | — | — | US | disclosed |
| US-7803806-B2 | Pyrimidinyl-thiophene kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2010-09-28 | — | — | US | disclosed |
| US-20070117800-A1 | PYRIMIDINYL-THIOPHENE KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2007-05-24 | — | — | US | disclosed |
| US-20070117800-A1 | PYRIMIDINYL-THIOPHENE KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2007-05-24 | — | — | US | disclosed |
| WO-2007053776-A1 | PYRIMIDINYL-THIOPHENE KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2007-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305128-A1 | Pyrimidinyl-Thiophene Kinase Modulators | MAP3K20, MAP3K6, MAP4K2 | PIK3CG 280/4885PIK3CA 241/4885CDK2 110/4885 |
| US-20070117800-A1 | PYRIMIDINYL-THIOPHENE KINASE MODULATORS | MAP3K20, MAP3K6, MAP4K2 | PIK3CG 280/4885PIK3CA 241/4885CDK2 110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.