Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2C
The experimentally established mechanism targets of Phenoxybenzamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.97 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.97 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.97 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | TSHR | P16473 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | GLA | P06280 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | HSPD1 | P10809 | 1/20 | 1.00 |
| ▸ | THRB | P10828 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | HSPE1 | P61604 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenoxybenzamine SCHEMBL202823 | 0.99 | SMN1; SMN2 (1.00) | ALDH1A1TSHRSMN1; SMN2LMNAKDM4E | |
| Phenoxybenzamine SCHEMBL5722 | 0.99 | SMN1; SMN2 (1.00) | ALDH1A1TSHRSMN1; SMN2LMNAKDM4E | |
| Phenoxybenzamine SCHEMBL1133740 | 0.96 | SMN1; SMN2 (0.94) | ALDH1A1TSHRSMN1; SMN2LMNAKDM4E | |
| Phenoxybenzamine SCHEMBL14894820 | 0.89 | SMN1; SMN2 (0.81) | ALDH1A1TSHRSMN1; SMN2LMNAKDM4E | |
| Phenoxybenzamine SCHEMBL11992656 | 0.85 | ALDH1A1 (0.76) | ALDH1A1TSHRSMN1; SMN2LMNAKDM4E | |
| SCHEMBL15960915 | 0.85 | ALDH1A1 (0.76) | ALDH1A1TSHRSMN1; SMN2LMNAKDM4E | |
| SCHEMBL19958436 | 0.84 | ALDH1A1 (0.74) | ALDH1A1TSHRSMN1; SMN2LMNAKDM4E | |
| SCHEMBL11077715 | 0.84 | SMN1; SMN2 (0.74) | ALDH1A1TSHRSMN1; SMN2LMNAKDM4E | |
| SCHEMBL11682499 | 0.83 | TSHR (0.72) | ALDH1A1TSHRSMN1; SMN2LMNAKDM4E | |
| SCHEMBL11684275 | 0.82 | SMN1; SMN2 (0.71) | ALDH1A1TSHRSMN1; SMN2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2566 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| CN-113687010-B | Method for accurately distinguishing echinoid-intermediate ball echinoid from commercial gonad of echinoid | 大连海洋大学 | 2023-09-15 | — | — | CN | claimed |
| EP-4232004-A1 | FRACTAL FORMULATIONS | Nanogyre Sprl (BE) | 2023-08-30 | — | — | EP | claimed |
| CN-111743871-B | Phenobenzmine hydrochloride tablet and preparation method thereof | 天方药业有限公司 | 2022-04-19 | — | — | CN | claimed |
| WO-2021078412-A1 | FRACTAL FORMULATIONS | MESSADEK JALLAL (BE) | 2021-04-29 | — | — | WO | claimed |
| CN-106659789-B | CYP2J2 antagonists in the treatment of pain | 弗劳恩霍夫应用研究促进协会 | 2020-11-03 | — | — | CN | claimed |
| CN-111743871-A | Phenobenzmine hydrochloride tablet and preparation method thereof | 天方药业有限公司 | 2020-10-09 | — | — | CN | claimed |
| US-20200147076-A1 | PARENTERAL FORMULATIONS OF LIPOPHILIC PHARMACEUTICAL AGENTS AND METHODS FOR PREPARING AND USING THE SAME | PLATFORM BRIGHTWORKS TWO, LTD. (US) | 2020-05-14 | — | — | US | claimed |
| US-20200121652-A1 | COMPOUNDS HAVING CASPASE INHIBITORY ACTIVITY, PHARMACEUTICAL AGENT CONTAINING SAID COMPOUNDS AND FOR TREATING OR PREVENTING CORNEAL ENDOTHELIAL SYMPTOMS, DISORDERS, OR DISEASES, AND APPLICATION OF SAID PHARMACEUTICAL AGENT | THE DOSHISHA (JP) | 2020-04-23 | — | — | US | claimed |
| EP-3639855-A1 | COMPOUNDS HAVING CASPASE INHIBITORY ACTIVITY, PHARMACEUTICAL AGENT CONTAINING SAID COMPOUNDS AND FOR TREATING OR PREVENTING CORNEAL ENDOTHELIAL SYMPTOMS, DISORDERS, OR DISEASES, AND APPLICATION OF SAID PHARMACEUTICAL AGENT | The Doshisha (JP) | 2020-04-22 | — | — | EP | claimed |
| WO-1995010275-A1 | USE OF ALPHA RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CHRONIC MUSCLE PAIN | HUBBARD DAVID R JR (US) | 1995-04-20 | — | — | WO | claimed |
| US-5399581-A | Method and compositions for treatment of sexual impotence | LARAGH JOHN H (US) | 1995-03-21 | — | — | US | claimed |
| US-5328453-A | Method for enhancing transdermal drug delivery of electrical drug applicators | DRUG DELIVERY SYSTEMS INC. (US) | 1994-07-12 | — | — | US | claimed |
| CN-1078886-A | New medicine \" Zhulinan \" for treating prostatic hyperplasia and uropathy | YU CHANGHU (CN) | 1993-12-01 | — | — | CN | claimed |
| US-5261876-A | Enhanced peritoneal membrane plasmapheresis | MONCRIEF-POPOVICH RESEARCH INSTITUTE, INC. (US) | 1993-11-16 | — | — | US | claimed |
| WO-1992011851-A1 | METHOD AND COMPOSITIONS FOR TREATMENT OF SEXUAL IMPOTENCE | LARAGH JOHN H (US) | 1992-07-23 | — | — | WO | claimed |
| US-4832684-A | PROTEIN REMOVAL; INFUSION OF VASODILATOR THEN DRAINAGE | POPOVICH ROBERT P (US) | 1989-05-23 | — | — | US | claimed |
| US-4673385-A | INFUSION OF SOLUTION CONTAINING VASODILATOR THEN DRAINAGE FOR TREATMENT OF PLASMA PROTEIN DISEASES | POPOVICH ROBERT P | 1987-06-16 | — | — | US | claimed |
| US-4532135-A | Treating renal damage by administering vasodilator having postsynaptic alpha-adrenoceptor blocking activity and antihyperlipidemic characteristics | EDWARDS K DAVID G | 1985-07-30 | — | — | US | claimed |
| US-4022893-A | Treatment for hypertension | MOYER JOHN H | 1977-05-10 | — | — | US | claimed |