SCHEMBL11684275

SCHEMBL11684275

CCN(Cc1ccccc1)C(C)COc1ccccc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.71
TSHR P16473 3/20 0.71
ALDH1A1 P00352 3/20 0.71
ADRA2B P18089 2/20 0.71
ADRA2C P18825 2/20 0.71
SLC6A2 P23975 2/20 0.71
HTR2A P28223 2/20 0.71
ADRA1A P35348 2/20 0.71
SLC6A3 Q01959 2/20 0.71
KCNH2 Q12809 2/20 0.71
CYP2D6 P10635 2/20 0.71
SLC22A2 O15244 1/20 0.71
SLC22A1 O15245 1/20 0.71
SLC22A3 O75751 1/20 0.71
ESR1 P03372 1/20 0.71
CHRM2 P08172 1/20 0.71
HTR1A P08908 1/20 0.71
ADRA2A P08913 1/20 0.71
ADORA3 P0DMS8 1/20 0.71
CHRM1 P11229 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15960915 0.88 ALDH1A1 (0.76) SMN1; SMN2TSHRALDH1A1ADRA2BADRA2C
SCHEMBL20909856 0.86 ALDH1A1 (0.55) SMN1; SMN2TSHRALDH1A1ADRA2BADRA2C
SCHEMBL11682499 0.85 TSHR (0.72) SMN1; SMN2TSHRALDH1A1ADRA2BADRA2C
SCHEMBL19479501 0.83 BCHE (0.52) SMN1; SMN2TSHRALDH1A1ADRA2BADRA2C
Phenoxybenzamine SCHEMBL202823 0.83 SMN1; SMN2 (1.00) SMN1; SMN2TSHRALDH1A1ADRA2BADRA2C
SCHEMBL11077715 0.83 SMN1; SMN2 (0.74) SMN1; SMN2TSHRALDH1A1ADRA2BADRA2C
SCHEMBL19958436 0.83 ALDH1A1 (0.74) SMN1; SMN2TSHRALDH1A1ADRA2BADRA2C
Phenoxybenzamine SCHEMBL5722 0.83 SMN1; SMN2 (1.00) SMN1; SMN2TSHRALDH1A1ADRA2BADRA2C
SCHEMBL20910106 0.82 TSHR (0.50) SMN1; SMN2TSHRALDH1A1ADRA2BADRA2C
Phenoxybenzamine SCHEMBL50729 0.82 ALDH1A1 (1.00) SMN1; SMN2TSHRALDH1A1ADRA2BADRA2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018130942-A1 A PROCESS FOR THE PREPARATION OF PHENOXYBENZAMINE AUROBINDO PHARMA LIMITED (IN) 2018-07-19 WO disclosed
US-4041024-A FOR POLYAMIDES AND POLYURETHANES BAYER AKTIENGESELLSCHAFT (DT) 1977-08-09 US disclosed