SCHEMBL5073

SCHEMBL5073

Nc1ccc(OC(F)(F)F)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.50
CYP3A4 P08684 3/20 0.50
ALDH1A1 P00352 3/20 0.50
TSHR P16473 1/20 0.50
MAPT P10636 4/20 0.47
EPHX2 P34913 1/20 0.47
MAPK1 P28482 3/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
KDM4E B2RXH2 1/20 0.46
NOS3 P29474 2/20 0.44
NOS1 P29475 2/20 0.44
NOS2 P35228 2/20 0.44
KIF11 P52732 1/20 0.44
GPR3 P46089 1/20 0.43
NPC1 O15118 3/20 0.43
RAB9A P51151 3/20 0.43
MAOB P27338 2/20 0.43
AOC3 Q16853 1/20 0.43
GMNN O75496 1/20 0.43
USP2 O75604 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3785323 0.97 TDP1 (0.48) TDP1CYP3A4ALDH1A1TSHRMAPT
Hydrochloric Acid SCHEMBL8756363 0.97 TDP1 (0.48) TDP1CYP3A4ALDH1A1TSHRMAPT
SCHEMBL633116 0.93 ALDH1A1 (0.64) TDP1CYP3A4ALDH1A1TSHRMAPT
SCHEMBL1242144 0.93 KIF11 (0.52) TDP1CYP3A4ALDH1A1TSHRMAPT
Hydrochloric Acid SCHEMBL29386875 0.91 KIF11 (0.50) TDP1CYP3A4ALDH1A1TSHRMAPT
SCHEMBL3468452 0.87 MAPT (0.56) TDP1CYP3A4ALDH1A1TSHRMAPT
SCHEMBL31409197 0.87 PDE2A (0.45) TDP1CYP3A4ALDH1A1TSHRMAPT
SCHEMBL13636818 0.87 CYP19A1 (0.48) KDM4EMAOBAOC3MAOA
SCHEMBL2232071 0.87 APP (0.57) TDP1CYP3A4ALDH1A1TSHRMAPT
SCHEMBL28629299 0.87 MAPT (0.52) TDP1CYP3A4ALDH1A1TSHRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3749 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120064487-A Detection method of 4-trifluoromethoxy aniline related substances 石家庄四药有限公司 2025-05-30 CN claimed
CN-115784987-B Compound related to pneumonia as well as preparation method and application thereof and pharmaceutical composition 国科温州研究院(温州生物材料与工程研究所) 2025-05-27 CN claimed
CN-119591560-B Synthesis method of thifluzamide 湖南速博生物技术有限公司 2025-04-29 CN claimed
CN-115322107-B Method for preparing p-trifluoromethoxy aniline through continuous hydrogenation 金凯(辽宁)生命科技股份有限公司 2025-04-18 CN claimed
CN-119613279-A N-substituted benzene ring bioisostere and preparation method thereof 上海交通大学 2025-03-14 CN claimed
CN-119591560-A Synthesis method of thifluzamide 湖南速博生物技术有限公司 2025-03-11 CN claimed
CN-119462430-A Integrated synthesis method of chlorocarbonyl [4- (trifluoromethoxy) phenyl ] methyl carbamate 山东京博农化科技股份有限公司 2025-02-18 CN claimed
CN-119462748-A Preparation method of fluorine-containing carbazole phosphonic acid compound 浙江科技大学 2025-02-18 CN claimed
CN-118772041-A Bisphenol compound with halogen-containing side groups, and preparation method and application thereof 中国科学院大连化学物理研究所 2024-10-15 CN claimed
US-20240270970-A1 METHOD OF MANIPULATING HYDROPHILICITY AND HYDROPHOBICITY OF CONVENTIONAL DYE MOLECULES FOR TRACER APPLICATIONS SAUDI ARABIAN OIL COMPANY (SA) 2024-08-15 US claimed
WO-2002042303-A2 ACYL AND SULFONYL DERIVATIVES OF 6,9-DISUBSTITUTED 2-(TRANS-1,4-DIAMINOCYCLOHEXYL)-PURINES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS AVENTIS PHARMACEUTICALS INC. (US) 2002-05-30 WO claimed
JP-2002501024-A 2002-01-15 JP claimed
EP-1115693-A1 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL $i(TERTIARY)-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY Monsanto Company (US) 2001-07-18 EP claimed
EP-1051176-A1 SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS Aventis Pharmaceuticals Products Inc. (US) 2000-11-15 EP claimed
US-6114584-A Method of preparing brominated substituted anilines OCCIDENTAL CHEMICAL CORPORATION (US) 2000-09-05 US claimed
WO-2000018721-A1 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL TERTIARY-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY MONSANTO COMPANY (US) 2000-04-06 WO claimed
WO-1999037304-A1 SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) 1999-07-29 WO claimed
EP-0322643-B1 MEDICINES CONTAINING AS A MIXTURE INTERFERON AND 1-DESOXY-PIPERIDINOSES, PROCESS FOR THEIR MANUFACTURE AND THEIR USE BAYER AG (DE) 1991-07-24 EP claimed
US-4767757-A Acyloxythiophene-carboxamide fungicides, compositions and use BAYER AKTIENGESELLSCHAFT (DE) 1988-08-30 US claimed
EP-0241735-A2 Acyloxythiophene carbon amide BAYER AG (DE) 1987-10-21 EP claimed