Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPRB | P23467 | 1/20 | 0.36 |
| ▸ | PTPRE | P23469 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 12/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 12/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3588423 | 0.81 | GAA (0.43) | NPC1ALDH1A1MAPTRAB9AKMT2A | |
| SCHEMBL17620987 | 0.80 | ALDH1A1 (0.56) | NPC1ALDH1A1TP53MAPTRAB9A | |
| SCHEMBL17620969 | 0.78 | ALDH1A1 (0.55) | NPC1ALDH1A1TP53MAPTRAB9A | |
| SCHEMBL3593173 | 0.78 | NPC1 (0.34) | NPC1ALDH1A1TP53MAPTRAB9A | |
| SCHEMBL13455807 | 0.75 | HDAC6 (0.36) | NPC1ALDH1A1TP53MAPTRAB9A | |
| SCHEMBL17621010 | 0.73 | FABP4 (0.39) | NPC1ALDH1A1TP53MAPTRAB9A | |
| SCHEMBL3212977 | 0.71 | LIMK1 (0.35) | PTPRCPTPN2PTPN1PTPRBPTPRE | |
| SCHEMBL17620989 | 0.70 | FABP4 (0.38) | NPC1ALDH1A1TP53MAPTRAB9A | |
| SCHEMBL17620984 | 0.70 | MAPT (0.40) | NPC1ALDH1A1TP53MAPTRAB9A | |
| SCHEMBL3600663 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1909786-A2 | TRICYCLIC 6-ALKYLIDENE-PENEM ß-LACTAMASE INHIBITORS AND ß-LACTAM ANTIBIOTIC COMBINATION: A BROAD SPECTRUM ANTIBIOTIC | Wyeth a Corporation of the State of Delaware (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007027323-A2 | TRICYCLIC 6-ALKYLIDENE-PENEM β-LACTAMASE INHIBITORS AND β-LACTAM ANTIBIOTIC COMBINATION: A BROAD SPECTRUM ANTIBIOTIC | WYETH (US) | 2007-03-08 | — | — | WO | disclosed |