SCHEMBL5073267

SCHEMBL5073267

Cc1cc(O)c(C(C)(C)C)cc1CCCc1cc(C(C)(C)C)c(O)cc1C

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 5/20 0.52
ALDH1A1 P00352 5/20 0.52
SMN1; SMN2 Q16637 5/20 0.52
CYP1A2 P05177 2/20 0.52
KDM4E B2RXH2 1/20 0.52
MAPT P10636 1/20 0.52
ATP2A2 P16615 1/20 0.52
ATP2A3 Q93084 1/20 0.52
TP53 P04637 4/20 0.52
HIF1A Q16665 4/20 0.52
CYP3A4 P08684 2/20 0.52
TSHR P16473 2/20 0.52
TDP1 Q9NUW8 2/20 0.52
MAPK1 P28482 1/20 0.52
CYP2C9 P11712 6/20 0.47
CYP2C19 P33261 5/20 0.47
CYP2D6 P10635 2/20 0.47
HSD17B10 Q99714 2/20 0.41
LMNA P02545 2/20 0.40
HPGD P15428 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2163484 0.96 ALOX15 (0.52) ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E
SCHEMBL30471645 0.96 ALOX15 (0.52) ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E
SCHEMBL9230440 0.92 ALOX15 (0.56) ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E
SCHEMBL529614 0.91 ALOX15 (0.51) ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E
SCHEMBL3125086 0.90 ALOX15 (0.50) ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E
SCHEMBL28650842 0.90 ALOX15 (0.46) ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E
SCHEMBL6537028 0.87 ALOX15 (0.54) ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E
SCHEMBL5083346 0.87 ALOX15 (0.48) ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E
SCHEMBL28382405 0.87 ALOX15 (0.48) ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E
SCHEMBL5083355 0.87 ALOX15 (0.48) ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1945695-A2 METHOD OF IMPROVING ABRASION RESISTANCE OF PLASTIC ARTICLE USING NANOPARTICLES AND ARTICLE PRODUCED THEREBY General Electric Company (US) 2008-07-23 EP disclosed
WO-2007047294-A2 METHOD OF IMPROVING ABRASION RESISTANCE OF PLASTIC ARTICLE USING NANOPARTICLES AND ARTICLE PRODUCED THEREBY GENERAL ELECTRIC COMPANY (US) 2007-04-26 WO disclosed