Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 8/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15308221 | 0.86 | CHRM2 (0.48) | CHRM2CHRM1KCNH2MEN1KMT2A | |
| Hexocyclium SCHEMBL934371 | 0.81 | CHRM2 (1.00) | CHRM2CHRM1KCNH2MEN1KMT2A | |
| Hexocyclium SCHEMBL25730 | 0.77 | CHRM2 (0.81) | CHRM2CHRM1KCNH2MEN1KMT2A | |
| Hexocyclium SCHEMBL4323226 | 0.77 | CHRM2 (0.81) | CHRM2CHRM1KCNH2MEN1KMT2A | |
| Hexocyclium SCHEMBL10747435 | 0.75 | CHRM2 (0.76) | CHRM2CHRM1KCNH2MEN1KMT2A | |
| SCHEMBL5166775 | 0.73 | CHRM2 (0.74) | CHRM2CHRM1KCNH2MEN1KMT2A | |
| SCHEMBL9660473 | 0.71 | CHRM2 (0.81) | CHRM2CHRM1KCNH2MEN1KMT2A | |
| Hexocyclium SCHEMBL6665502 | 0.70 | CHRM2 (0.67) | CHRM2CHRM1KCNH2MEN1KMT2A | |
| Poldine SCHEMBL28086707 | 0.68 | CHRM2 (0.67) | CHRM2CHRM1KCNH2CHRM3CYP2D6 | |
| SCHEMBL11879574 | 0.65 | CHRM2 (0.72) | CHRM2CHRM1KCNH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130267506-A1 | THERAPEUTIC COMPOSITIONS FOR DIABETIC SYMMETRICAL POLYNEUROPATHY | UNIVERSITY OF MANITOBA (CA) | 2013-10-10 | — | — | US | disclosed |
| WO-2012055018-A1 | THERAPEUTIC COMPOSITIONS FOR DIABETIC SYMMETRICAL POLYNEUROPATHY | UNIVERSITY OF MANITOBA (CA) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130267506-A1 | THERAPEUTIC COMPOSITIONS FOR DIABETIC SYMMETRICAL POLYNEUROPATHY | CHRNA5, CHRM2, GAP43 | CHRM2 2/4885CHRM1 18/4885KCNH2 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.