Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hexocyclium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 6/20 | 1.00 |
| ▸ | CHRM3 known ✓ | P20309 | 4/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 8/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.56 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.56 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.56 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.56 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.56 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hexocyclium SCHEMBL4323226 | 0.90 | CHRM2 (0.81) | CHRM2CHRM1KCNH2CYP2D6CHRM3 | |
| Hexocyclium SCHEMBL25730 | 0.90 | CHRM2 (0.81) | CHRM2CHRM1KCNH2CYP2D6CHRM3 | |
| SCHEMBL9660473 | 0.90 | CHRM2 (0.81) | CHRM2CHRM1KCNH2CYP2D6CHRM3 | |
| Hexocyclium SCHEMBL10747435 | 0.87 | CHRM2 (0.76) | CHRM2CHRM1KCNH2CYP2D6CHRM3 | |
| SCHEMBL5166775 | 0.86 | CHRM2 (0.74) | CHRM2CHRM1KCNH2CYP2D6CHRM3 | |
| SCHEMBL11879574 | 0.84 | CHRM2 (0.72) | CHRM2CHRM1KCNH2CYP2D6CHRM3 | |
| Hexocyclium SCHEMBL6665502 | 0.82 | CHRM2 (0.67) | CHRM2CHRM1KCNH2CYP2D6CHRM3 | |
| Poldine SCHEMBL28086707 | 0.82 | CHRM2 (0.67) | CHRM2CHRM1KCNH2CYP2D6CHRM3 | |
| SCHEMBL10518509 | 0.81 | CHRM2 (0.68) | CHRM2CHRM1KCNH2CYP2D6CHRM3 | |
| SCHEMBL5073643 | 0.81 | CHRM2 (0.67) | CHRM2CHRM1KCNH2CYP2D6CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 630 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250302814-A1 | METHODS AND COMPOSITIONS FOR TREATING SLEEP APNEA | APNIMED, INC. (DELAWARE) | 2025-10-02 | — | — | US | claimed |
| EP-4154879-B1 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING NICOTINE WITHDRAWAL SYMPTOMS | KOREA INST SCI & TECH (KR) | 2025-09-10 | — | — | EP | claimed |
| US-20250241933-A1 | METHODS OF TREATING SLEEP APNEA WITH A COMBINATION OF A CANNABINOID AND A CARBONIC ANHYDRASE INHIBITOR | APNIMED, INC. (DELAWARE) | 2025-07-31 | — | — | US | claimed |
| WO-2025111482-A1 | COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS | BEXSON BIOMEDICAL, INC. (US) | 2025-05-30 | — | — | WO | claimed |
| EP-4543431-A1 | METHODS OF TREATING SLEEP APNEA WITH A COMBINATION OF A CANNABINOID AND A CARBONIC ANHYDRASE INHIBITOR | APNIMED, INC. (DELAWARE) (US) | 2025-04-30 | — | — | EP | claimed |
| US-20240358709-A1 | METHODS AND COMPOSITIONS FOR TREATING SLEEP APNEA | APNIMED, INC. (DELAWARE) | 2024-10-31 | — | — | US | claimed |
| EP-3863708-B1 | MIXED IONIC CONDUCTORS AND CORRESPONDING DEVICES, SYSTEMS AND METHODS OF MAKING | BATTELLE MEMORIAL INSTITUTE (US) | 2024-09-11 | — | — | EP | claimed |
| US-20240261239-A1 | METHODS AND COMPOSITIONS FOR TREATING SLEEP APNEA | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2024-08-08 | — | — | US | claimed |
| EP-4395721-A1 | METHODS AND COMPOSITIONS FOR TREATING SLEEP APNEA | APNIMED, INC. (DELAWARE) (US) | 2024-07-10 | — | — | EP | claimed |
| US-20240189261-A1 | METHODS AND COMPOSITIONS FOR TREATING SLEEP APNEA | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2024-06-13 | — | — | US | claimed |
| US-20070116729-A1 | Lyophilization process and products obtained thereby | SCIDOSE LLC | 2007-05-24 | — | — | US | claimed |
| US-20050054991-A1 | Topical administration device | PHARMAKODEX LIMITED (GB) | 2005-03-10 | — | — | US | claimed |
| EP-1455888-A2 | TOPICAL ADMINISTRATION DEVICE | Vectura Limited (GB) | 2004-09-15 | — | — | EP | claimed |
| US-20040082644-A1 | Compositions and methods for bowel care in individuals with chronic intestinal pseudo-obstruction | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, DBA, THE DEPARTMENT OF VETERANS AFFAIRS | 2004-04-29 | — | — | US | claimed |
| WO-2003018102-A2 | TOPICAL ADMINISTRATION DEVICE | VECTURA LIMITED (US) | 2003-03-06 | — | — | WO | claimed |
| CN-1294519-A | Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient | INPHARMA SA (CH) | 2001-05-09 | — | — | CN | claimed |
| EP-0721348-A1 | MONOGLYCERIDE/LACTATE ESTER PERMEATION ENHANCER | ALZA CORPORATION (US) | 1996-07-17 | — | — | EP | claimed |
| WO-1995009006-A1 | MONOGLYCERIDE/LACTATE ESTER PERMEATION ENHANCER | ALZA CORPORATION (US) | 1995-04-06 | — | — | WO | claimed |
| US-5153205-A | Administering cholinergic M3 receptor antagonist along with cholinomimetic agent | MERCK & CO., INC. (US) | 1992-10-06 | — | — | US | claimed |
| EP-0479524-A1 | Method to reduce intraocular pressure without causing miosis | MERCK & CO. INC. (US) | 1992-04-08 | — | — | EP | claimed |