SCHEMBL5166775

SCHEMBL5166775

CO[SiH2][N+]1(C)CCN(CC(O)(c2ccccc2)C2CCCCC2)CC1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 9/20 0.74
CHRM1 P11229 6/20 0.74
KCNH2 Q12809 5/20 0.74
CHRM3 P20309 5/20 0.50
CYP2D6 P10635 4/20 0.50
CHRM4 P08173 3/20 0.50
CHRM5 P08912 3/20 0.50
TSHR P16473 2/20 0.50
HRH1 P35367 2/20 0.50
GRIN2D O15399 1/20 0.50
GRIN3B O60391 1/20 0.50
GRIN1 Q05586 1/20 0.50
GRIN2A Q12879 1/20 0.50
GRIN2B Q13224 1/20 0.50
GRIN2C Q14957 1/20 0.50
GRIN3A Q8TCU5 1/20 0.50
CYP3A4 P08684 1/20 0.50
NFKB1 P19838 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
HTR1A P08908 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hexocyclium SCHEMBL934371 0.86 CHRM2 (1.00) CHRM2CHRM1KCNH2CHRM3CYP2D6
SCHEMBL9660473 0.83 CHRM2 (0.81) CHRM2CHRM1KCNH2CHRM3CYP2D6
Hexocyclium SCHEMBL25730 0.81 CHRM2 (0.81) CHRM2CHRM1KCNH2CHRM3CYP2D6
Hexocyclium SCHEMBL4323226 0.81 CHRM2 (0.81) CHRM2CHRM1KCNH2CHRM3CYP2D6
Hexocyclium SCHEMBL10747435 0.79 CHRM2 (0.76) CHRM2CHRM1KCNH2CHRM3CYP2D6
SCHEMBL11879574 0.78 CHRM2 (0.72) CHRM2CHRM1KCNH2CHRM3CYP2D6
SCHEMBL10518509 0.75 CHRM2 (0.68) CHRM2CHRM1KCNH2CHRM3CYP2D6
SCHEMBL10519164 0.74 CHRM2 (0.67) CHRM2CHRM1KCNH2CHRM3CYP2D6
Hexocyclium SCHEMBL6665502 0.74 CHRM2 (0.67) CHRM2CHRM1KCNH2CHRM3CYP2D6
SCHEMBL5073643 0.73 CHRM2 (0.67) CHRM2CHRM1KCNH2CHRM3CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1773788-A2 QUINAZOLINE DERIVATIVES NOVARTIS-PHARMA GMBH (AT) 2007-04-18 EP disclosed
WO-2006010591-A2 QUINAZOLINE DERIVATIVES NOVARTIS AG (CH) 2006-02-02 WO disclosed
WO-2005039594-A1 COMBINATIONS COMPRISING AMPA RECEPTOR ANTAGONISTS FOR THE TREATMENT OF MYOPIA NOVARTIS AG (CH) 2005-05-06 WO disclosed