Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5073565 | 0.82 | KDM4E (0.38) | ALDH1A1HSD17B10POLBKDM4EHPGD | |
| SCHEMBL3142092 | 0.79 | KDM4E (0.46) | CYP1A2ALDH1A1HSD17B10POLBKDM4E | |
| SCHEMBL3135783 | 0.78 | KDM4E (0.43) | CYP1A2ALDH1A1HSD17B10POLBKDM4E | |
| SCHEMBL3135791 | 0.78 | KDM4E (0.43) | CYP1A2ALDH1A1HSD17B10POLBKDM4E | |
| SCHEMBL3140997 | 0.78 | THRA (0.55) | CYP1A2ALDH1A1HSD17B10POLBKDM4E | |
| SCHEMBL8103092 | 0.75 | POLB (0.66) | CYP1A2ALDH1A1HSD17B10POLBKDM4E | |
| SCHEMBL30048942 | 0.71 | CYP1A2 (0.57) | CYP1A2ALDH1A1POLBKDM4ELMNA | |
| SCHEMBL15724648 | 0.71 | CYP1A2 (0.57) | CYP1A2ALDH1A1POLBKDM4ELMNA | |
| SCHEMBL19983503 | 0.71 | ALDH1A1 (0.67) | CYP1A2ALDH1A1HSD17B10POLBCASP1 | |
| SCHEMBL1161098 | 0.69 | POLB (0.60) | ALDH1A1HSD17B10POLBKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899309-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003419-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2007-01-11 | — | — | WO | disclosed |