Bicarbonate

Bicarbonate

SCHEMBL5074471

CCCCOc1ccc(Cl)cc1C.O=C(O)O

nearest known ligand 0.65

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Known targets — ChEMBL curated mechanism

GSK3AGSK3BIMPA1

The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.63
TP53 P04637 1/20 0.63
ALOX15 P16050 1/20 0.63
ALDH1A1 P00352 3/20 0.62
HTT P42858 1/20 0.60
GAA P10253 1/20 0.59
MEN1 O00255 2/20 0.58
KMT2A Q03164 2/20 0.58
HPGD P15428 3/20 0.56
RAB9A P51151 2/20 0.56
NPSR1 Q6W5P4 2/20 0.56
NPC1 O15118 1/20 0.56
CYP1A2 P05177 2/20 0.55
CYP3A4 P08684 1/20 0.55
CYP2D6 P10635 1/20 0.55
CYP2C19 P33261 1/20 0.55
TDP1 Q9NUW8 1/20 0.55
L3MBTL1 Q9Y468 1/20 0.55
PPARG P37231 1/20 0.53
PPARD Q03181 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8347835 0.92 KDM4E (0.59) KDM4ETP53ALOX15ALDH1A1HTT
SCHEMBL14015785 0.85 KDM4E (0.56) KDM4ETP53ALOX15ALDH1A1HTT
Mcpb SCHEMBL117879 0.84 KDM4E (0.72) KDM4ETP53ALOX15ALDH1A1HTT
Mcpb SCHEMBL29150193 0.84 KDM4E (0.72) KDM4ETP53ALOX15ALDH1A1HTT
Mcpb SCHEMBL29355091 0.84 KDM4E (0.72) KDM4ETP53ALOX15ALDH1A1HTT
SCHEMBL4884515 0.84 ALDH1A1 (0.78) KDM4ETP53ALOX15ALDH1A1HTT
SCHEMBL8234481 0.83 KDM4E (0.56) KDM4ETP53ALOX15ALDH1A1HTT
SCHEMBL5074470 0.83 KDM4E (0.66) KDM4ETP53ALOX15ALDH1A1HTT
Mcpb SCHEMBL5250457 0.83 KDM4E (0.70) KDM4ETP53ALOX15ALDH1A1HTT
SCHEMBL22135588 0.83 KDM4E (0.64) KDM4ETP53ALOX15ALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4118948-B2 2008-07-16 JP claimed
EP-0861026-B1 SYNERGISTIC HERBICIDAL MIXTURES CONTAINING CYCLOHEXENONE OXIME ETHER BASF AG (DE) 2003-04-02 EP claimed
JP-2000503297-A 2000-03-21 JP claimed
EP-0861026-A1 SYNERGISTIC HERBICIDAL MIXTURES CONTAINING CYCLOHEXENONE OXIME ETHER BASF AKTIENGESELLSCHAFT (DE) 1998-09-02 EP claimed
WO-1997010710-A1 SYNERGISTIC HERBICIDAL MIXTURES CONTAINING CYCLOHEXENONE OXIME ETHER BASF AKTIENGESELLSCHAFT (DE) 1997-03-27 WO claimed
EP-0861026-B1 SYNERGISTIC HERBICIDAL MIXTURES CONTAINING CYCLOHEXENONE OXIME ETHER BASF AG (DE) 2003-04-02 EP disclosed
EP-0861026-A1 SYNERGISTIC HERBICIDAL MIXTURES CONTAINING CYCLOHEXENONE OXIME ETHER BASF AKTIENGESELLSCHAFT (DE) 1998-09-02 EP disclosed
WO-1997010710-A1 SYNERGISTIC HERBICIDAL MIXTURES CONTAINING CYCLOHEXENONE OXIME ETHER BASF AKTIENGESELLSCHAFT (DE) 1997-03-27 WO disclosed