Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 4/20 | 0.43 |
| ▸ | PDE2A | O00408 | 4/20 | 0.41 |
| ▸ | MERTK | Q12866 | 5/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.40 |
| ▸ | AXL | P30530 | 4/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5081049 | 0.96 | ACVRL1 (0.44) | ACVRL1MERTKTYRO3AXL | |
| SCHEMBL5153730 | 0.95 | ACVRL1 (0.44) | ACVRL1MERTKTYRO3AXL | |
| SCHEMBL14313012 | 0.92 | ACVRL1 (0.41) | ACVRL1PDE2AMERTKTNK2TYRO3 | |
| SCHEMBL5077750 | 0.92 | ACVRL1 (0.47) | ACVRL1MERTKTYRO3AXL | |
| SCHEMBL14327105 | 0.92 | MERTK (0.41) | ACVRL1PDE2AMERTKTNK2TYRO3 | |
| SCHEMBL14312938 | 0.92 | ACVRL1 (0.40) | ACVRL1PDE2AMERTKTNK2TYRO3 | |
| SCHEMBL14312940 | 0.92 | ACVRL1 (0.40) | ACVRL1PDE2AMERTKTNK2TYRO3 | |
| SCHEMBL14312883 | 0.91 | TYRO3 (0.42) | ACVRL1PDE2AMERTKTYRO3AXL | |
| SCHEMBL14312740 | 0.91 | ACVRL1 (0.43) | ACVRL1PDE2AMERTKTYRO3 | |
| SCHEMBL14313235 | 0.91 | TYRO3 (0.42) | ACVRL1PDE2AMERTKTYRO3AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945222-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | Bayer HealthCare AG (DE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007056170-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | BAYER HEALTHCARE AG (DE) | 2007-05-18 | — | — | WO | disclosed |