Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 2/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 12/20 | 0.43 |
| ▸ | MERTK | Q12866 | 7/20 | 0.42 |
| ▸ | AXL | P30530 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5074877 | 0.96 | ACVRL1 (0.43) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL5077750 | 0.95 | ACVRL1 (0.47) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL14312988 | 0.94 | TYRO3 (0.48) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL5153730 | 0.94 | ACVRL1 (0.44) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL5080203 | 0.93 | ACVRL1 (0.42) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL14313354 | 0.93 | ACVRL1 (0.44) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL14313195 | 0.93 | MERTK (0.47) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL14312385 | 0.93 | TYRO3 (0.49) | TYRO3MERTKAXL | |
| SCHEMBL14531768 | 0.91 | TYRO3 (0.42) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL14898479 | 0.91 | TYRO3 (0.44) | ACVRL1TYRO3MERTKAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945222-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | Bayer HealthCare AG (DE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007056170-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | BAYER HEALTHCARE AG (DE) | 2007-05-18 | — | — | WO | disclosed |