Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LHCGR | P22888 | 4/20 | 0.58 |
| ▸ | BRAF | P15056 | 5/20 | 0.51 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | IKBKB | O14920 | 7/20 | 0.45 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.41 |
| ▸ | EEF2K | O00418 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4907962 | 0.80 | BRAF (0.79) | LHCGRBRAFPDE4APDE4BPDE4C | |
| SCHEMBL4907366 | 0.80 | LHCGR (0.55) | LHCGRBRAFPDE4APDE4BPDE4C | |
| SCHEMBL5078586 | 0.78 | IKBKB (0.47) | LHCGRBRAFPDE4APDE4BPDE4C | |
| SCHEMBL4898031 | 0.78 | BRAF (0.77) | LHCGRBRAFPDE4APDE4BPDE4C | |
| SCHEMBL4318474 | 0.73 | LHCGR (1.00) | LHCGRBRAFPDE4APDE4BPDE4C | |
| SCHEMBL27492291 | 0.71 | LIMK1 (0.56) | LHCGRBRAFPDE4APDE4BPDE4C | |
| SCHEMBL14281617 | 0.70 | BRAF (0.66) | LHCGRBRAFPDE4APDE4BPDE4C | |
| SCHEMBL27473526 | 0.68 | IKBKB (0.55) | LHCGRIKBKBLIMK1 | |
| SCHEMBL4903726 | 0.67 | BRAF (0.69) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4912160 | 0.67 | BRAF (1.00) | LHCGRBRAFPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984377-A2 | INHIBITORS OF TNF ALPHA , PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH | Signal Pharmaceuticals LLC (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007084560-A2 | INHIBITORS OF TNFα, PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-07-26 | — | — | WO | disclosed |