Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 8/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.44 |
| ▸ | BRAF | P15056 | 4/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | CDK8 | P49336 | 3/20 | 0.43 |
| ▸ | CDK19 | Q9BWU1 | 3/20 | 0.43 |
| ▸ | LHCGR | P22888 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4902938 | 0.81 | LHCGR (0.55) | IKBKBLIMK1BRAFPDE4APDE4B | |
| SCHEMBL4898964 | 0.79 | BRAF (0.69) | IKBKBLIMK1BRAFPDE4APDE4B | |
| SCHEMBL4907032 | 0.79 | IKBKB (0.48) | IKBKBLIMK1BRAFPDE4APDE4B | |
| SCHEMBL5075320 | 0.78 | LHCGR (0.58) | IKBKBLIMK1BRAFPDE4APDE4B | |
| SCHEMBL14281674 | 0.72 | BRAF (0.59) | IKBKBLIMK1BRAFPDE4APDE4B | |
| SCHEMBL4909475 | 0.66 | BRAF (0.70) | IKBKBLIMK1BRAFPDE4APDE4B | |
| SCHEMBL4658241 | 0.65 | IKBKB (1.00) | IKBKBLIMK1BRAFCDK8CDK19 | |
| SCHEMBL6218854 | 0.64 | BRAF (0.64) | IKBKBLIMK1BRAFPDE4APDE4B | |
| SCHEMBL14466308 | 0.64 | BRAF (0.49) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2130627 | 0.64 | IKBKB (0.49) | IKBKBLIMK1BRAFPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984377-A2 | INHIBITORS OF TNF ALPHA , PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH | Signal Pharmaceuticals LLC (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007084560-A2 | INHIBITORS OF TNFα, PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-07-26 | — | — | WO | disclosed |