Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 2/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5285564 | 0.73 | MAPK14 (0.38) | MAPK14HDAC6 | |
| SCHEMBL3051840 | 0.72 | TSHR (0.37) | MAPK14ALDH1A1MAPT | |
| SCHEMBL3054278 | 0.70 | MAPK14 (0.59) | MAPK14NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL5076262 | 0.70 | MAPK14 (0.40) | MAPK14ALDH1A1 | |
| SCHEMBL5138721 | 0.70 | MAPK14 (0.47) | MAPK14NPC1ALDH1A1RAB9A | |
| SCHEMBL3051914 | 0.69 | MAPK14 (0.39) | MAPK14 | |
| SCHEMBL3051000 | 0.69 | MAPK14 (0.48) | MAPK14NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL3061264 | 0.69 | MAPK14 (0.48) | MAPK14NPC1MAPTSMN1; SMN2 | |
| SCHEMBL3048385 | 0.69 | MAPK14 (0.65) | MAPK14 | |
| SCHEMBL3056347 | 0.69 | MAPK14 (0.43) | MAPK14NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907358-A2 | BICYCLIC DERIVATIVES AS P38 KINASE INHIBITORS | Palau Pharma, S.A. (ES) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007000340-A2 | BICYCLIC DERIVATIVES AS P38 KINASE INHIBITORS | PALAU PHARMA, S.A. (ES) | 2007-01-04 | — | — | WO | disclosed |