Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5296159 | 0.83 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3051840 | 0.82 | TSHR (0.37) | MAPK14MAPK13MAPK12MAPK11GRM1 | |
| SCHEMBL3063392 | 0.80 | MAPK14 (0.50) | MAPK14RAPGEF4 | |
| SCHEMBL5286949 | 0.78 | MAPK14 (0.41) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3051914 | 0.77 | MAPK14 (0.39) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27706509 | 0.74 | MAPK14 (0.34) | MAPK14MAPK13MAPK12MAPK11GRM1 | |
| SCHEMBL27727217 | 0.73 | ALDH1A1 (0.48) | — | |
| SCHEMBL5293741 | 0.73 | MAPK14 (0.58) | MAPK14 | |
| SCHEMBL5075615 | 0.73 | MAPK14 (0.34) | MAPK14HDAC6 | |
| SCHEMBL5289299 | 0.72 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007000337-A1 | BICYCLIC DERIVATIVES AS P38 KINASE INHIBITORS | PALAU PHARMA, S.A. (ES) | 2007-01-04 | — | — | WO | claimed |
| WO-2007000337-A1 | BICYCLIC DERIVATIVES AS P38 KINASE INHIBITORS | PALAU PHARMA, S.A. (ES) | 2007-01-04 | — | — | WO | disclosed |