Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA7 | P43166 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8531963 | 0.83 | CA12 (0.50) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL8533452 | 0.80 | PDGFRB (0.47) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL9324585 | 0.78 | CA12 (0.48) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL10399338 | 0.77 | RAB9A (0.44) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL9827926 | 0.77 | ESR1 (0.52) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL15425 | 0.76 | ALDH1A1 (0.70) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL5190217 | 0.76 | ALDH1A1 (0.70) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL8531974 | 0.76 | MAPT (0.52) | MAPTNPC1RAB9AALDH1A1LMNA | |
| Ammonia Solution, Strong SCHEMBL11211951 | 0.75 | ALDH1A1 (0.68) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL8064164 | 0.75 | ALDH1A1 (0.44) | MAPTALDH1A1LMNASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007373-A2 | INHIBITION OF ALPHA-SYNUCLEIN TOXICITY | Foldrx Pharmaceuticals, Inc. (US) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007126841-A2 | INHIBITION OF ALPHA-SYNUCLEIN TOXICITY | FOLDRX PHARMACEUTICALS, INC. (US) | 2007-11-08 | — | — | WO | disclosed |