SCHEMBL5076353

SCHEMBL5076353

Oc1cc(Cl)c(OCC2CC2)c(Cl)c1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CHUK O15111 2/20 0.41
RHEB Q15382 3/20 0.40
THRA P10827 2/20 0.39
THRB P10828 2/20 0.39
CYP3A4 P08684 1/20 0.38
HPGD P15428 1/20 0.38
CRHBP P24387 1/20 0.38
CRHR2 Q13324 1/20 0.38
HSD17B10 Q99714 1/20 0.38
HTR2A P28223 1/20 0.37
HTR2C P28335 1/20 0.37
PTGS1 P23219 1/20 0.36
APP P05067 1/20 0.36
KMO O15229 1/20 0.35
FFAR4 Q5NUL3 2/20 0.35
PDE4D Q08499 1/20 0.35
PARP15 Q460N3 1/20 0.35
PARP10 Q53GL7 1/20 0.35
PARP2 Q9UGN5 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13416777 0.85 HSP90AA1 (0.42)
SCHEMBL30126500 0.77 HTR2C (0.54) HPGDHSD17B10HTR2AHTR2CKMO
SCHEMBL3720289 0.77 HTR2C (0.54) HPGDHSD17B10HTR2AHTR2CKMO
SCHEMBL13416740 0.76 GPR119 (0.46) THRB
SCHEMBL30902455 0.75 THRA (0.38) CHUKRHEBTHRATHRBHPGD
SCHEMBL15093793 0.75 SCN9A (0.42) CHUK
SCHEMBL2088604 0.75 KDM4E (0.43) THRATHRBHSD17B10PDE4DPARP15
SCHEMBL22816641 0.74 F2 (0.40) HTR2AHTR2CPARP15PARP10PARP2
SCHEMBL17534303 0.74 CNR1 (0.46) HTR2AHTR2CPARP15PARP10PARP2
SCHEMBL17534133 0.74 PARP15 (0.46) HTR2AHTR2CPDE4DPARP15PARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7435844-B2 Analogous compounds of strobilurines and their use as acaricides and insecticides ISAGRO RICERCA S.R.L. (IT) 2008-10-14 US disclosed
US-20060235075-A1 Analogous compounds of strobilurines and their use as acaricides and insecticides ISAGRO RICERCA S.R.L. (IT) 2006-10-19 US disclosed
EP-1494991-A1 ANALOGOUS COMPOUNDS OF STROBILURINES AND THEIR USE AS ACARICIDES AND INSECTICIDES Isagro Ricerca S.r.l. (IT) 2005-01-12 EP disclosed
WO-2003087032-A1 ANALOGOUS COMPOUNDS OF STROBILURINES AND THEIR USE AS ACARICIDES AND INSECTICIDES ISAGRO RICERCA S.R.L. (IT) 2003-10-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060235075-A1 Analogous compounds of strobilurines and their use as acaricides and insecticides DDT, RYR1, TPMT CHUK 1173/4885RHEB 2836/4885THRA 3390/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.