Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SI | P14410 | 1/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1736699 | 0.82 | — | — | |
| SCHEMBL5074741 | 0.80 | GAA (0.56) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL529207 | 0.78 | MGAM (0.46) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL11607945 | 0.77 | MGAM (0.41) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL30477388 | 0.77 | TSHR (0.44) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL23391807 | 0.76 | MGAM (0.44) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL10211016 | 0.76 | GAA (0.44) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL27976 | 0.76 | MGAM (0.61) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL11911037 | 0.74 | MGAM (0.42) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL12562841 | 0.74 | TSHR (0.43) | MGAMGAASIMGAM2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083619-A1 | P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS | Asana BioSciences, LLC (US) | 2016-10-26 | — | — | EP | disclosed |
| WO-2015095128-A1 | P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS | ASANA BIOSCIENCES, LLC (US) | 2015-06-25 | — | — | WO | disclosed |
| EP-1765764-B1 | PROCESS FOR THE PREPARATION OF 4,4-DIFLUORO-3-OXOBUTANOIC ACID ESTERS | SYNGENTA PARTICIPATIONS AG (CH) | 2014-05-21 | — | — | EP | disclosed |
| CN-100532345-C | Process for the preparation of 4,4-difluoro-3-oxobutanoic acid esters | SYNGENTA PARTICIPATIONS AG (CH) | 2009-08-26 | — | — | CN | disclosed |
| US-7355065-B2 | Process for the preparation of 4,4-difluoro-3-oxobutanoic acid esters | SYNGENTA CROP PROTECTION, INC. (US) | 2008-04-08 | — | — | US | disclosed |
| US-20080004465-A1 | Process for the Preparation of 4,4-Difluoro-3-Oxobutanoic Acid Esters | SYNGENTA CROP PROTECTION, INC. | 2008-01-03 | — | — | US | disclosed |
| CN-1984865-A | Process for the preparation of 4,4-difluoro-3-oxobutanoic acid esters | SYNGENTA PARTICIPATIONS AG (CH) | 2007-06-20 | — | — | CN | disclosed |
| EP-1765764-A1 | PROCESS FOR THE PREPARATION OF 4,4-DIFLUORO-3-OXOBUTANOIC ACID ESTERS | Syngeta Participations AG (CH) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006005612-A1 | PROCESS FOR THE PREPARATION OF 4,4-DIFLUORO-3-OXOBUTANOIC ACID ESTERS | SYNGENTA PARTICIPATIONS AG (CH) | 2006-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004465-A1 | Process for the Preparation of 4,4-Difluoro-3-Oxobutanoic Acid Esters | FFAR4, OGDH, AKR1C4 | MGAM 3090/4885GAA 2819/4885SI 1849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.