Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 8/20 | 0.45 |
| ▸ | AXL | P30530 | 4/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 12/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313138 | 0.89 | MERTK (0.47) | MERTKAXLTYRO3ACVRL1 | |
| SCHEMBL14313010 | 0.88 | ACVRL1 (0.46) | MERTKAXLTYRO3ACVRL1 | |
| SCHEMBL14312512 | 0.83 | TYRO3 (0.52) | MERTKAXLTYRO3ACVRL1 | |
| SCHEMBL5081063 | 0.82 | MERTK (0.47) | MERTKAXLTYRO3ACVRL1 | |
| SCHEMBL14313391 | 0.82 | MERTK (0.47) | MERTKAXLTYRO3ACVRL1 | |
| SCHEMBL5077790 | 0.82 | TYRO3 (0.47) | MERTKAXLTYRO3ACVRL1 | |
| SCHEMBL14327120 | 0.82 | TYRO3 (0.53) | MERTKAXLTYRO3ACVRL1 | |
| SCHEMBL14888090 | 0.82 | ACVRL1 (0.47) | MERTKAXLTYRO3ACVRL1 | |
| SCHEMBL14313867 | 0.81 | TYRO3 (0.45) | MERTKAXLTYRO3ACVRL1 | |
| SCHEMBL5137209 | 0.81 | ACVRL1 (0.60) | MERTKAXLTYRO3ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945222-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | Bayer HealthCare AG (DE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007056170-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | BAYER HEALTHCARE AG (DE) | 2007-05-18 | — | — | WO | disclosed |