Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.72 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | CHKA | P35790 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31010136 | 0.89 | HRH3 (0.75) | HRH3L3MBTL3L3MBTL1HRH4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9397270 | 0.87 | HRH3 (0.72) | HRH3L3MBTL3L3MBTL1HRH4ALDH1A1 | |
| SCHEMBL27483128 | 0.86 | HRH3 (0.55) | HRH3L3MBTL3L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL4937224 | 0.84 | HRH3 (0.62) | HRH3L3MBTL3L3MBTL1HRH4HPGD | |
| SCHEMBL4938456 | 0.82 | HRH3 (0.64) | HRH3L3MBTL3L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL4940225 | 0.82 | L3MBTL3 (0.81) | HRH3L3MBTL3L3MBTL1 | |
| SCHEMBL4934935 | 0.82 | HRH3 (0.64) | HRH3L3MBTL3L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL5591867 | 0.82 | KDM4E (0.53) | HRH3L3MBTL3L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL28860078 | 0.81 | HRH3 (0.62) | HRH3L3MBTL3L3MBTL1HRH4ALDH1A1 | |
| SCHEMBL15467001 | 0.80 | HRH3 (0.87) | HRH3ALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562600-A4 | COMBINATION ADMINISTRATION OF AN INDOLINONE WITH A CHEMOTHERAPEUTIC AGENT FOR CELL PROLIFERATION DISORDERS | SUGEN INC (US) | 2008-06-25 | — | — | EP | disclosed |
| EP-1599207-A2 | TREATMENT OF EXCESSIVE OSTEOLYISIS WITH INDOLINONE COMPOUNDS | Sugen, Inc. (US) | 2005-11-30 | — | — | EP | disclosed |
| EP-1562600-A2 | COMBINATION ADMINISTRATION OF AN INDOLINONE WITH A CHEMOTHERAPEUTIC AGENT FOR CELL PROLIFERATION DISORDERS | Sugen, Inc. (US) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004075775-A2 | TREATMENT OF EXCESSIVE OSTEOLYISIS WITH INDOLINONE COMPOUNDS | SUGEN, INC. (US) | 2004-09-10 | — | — | WO | disclosed |
| EP-1434774-A1 | 3-(4-SUBSTITUTED HETEROCYCLYL)-PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Sugen, Inc. (US) | 2004-07-07 | — | — | EP | disclosed |
| WO-2004045523-A2 | COMBINATION ADMINISTRATION OF AN INDOLINONE WITH A CHEMOTHERAPEUTIC AGENT FOR CELL PROLIFERATION DISORDERS | SUGEN, INC. (US) | 2004-06-03 | — | — | WO | disclosed |
| WO-2003031438-A1 | 3-[4-(SUBSTITUTED HETEROCYCLYL)-PYRROL-2-YLMETHYLIDENE]-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS | SUGEN, INC. (US) | 2003-04-17 | — | — | WO | disclosed |