SCHEMBL5077545

SCHEMBL5077545

NC(=O)C1(NC(=O)OC2CCCC2)CCCC1

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 2/20 0.44
CYP2C19 P33261 1/20 0.40
MAPT P10636 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.35
OPRL1 P41146 3/20 0.34
IDO1 P14902 1/20 0.34
P2RX7 Q99572 1/20 0.33
PRSS1 P07477 1/20 0.33
TPSAB1 Q15661 1/20 0.33
TPSD1 Q9BZJ3 1/20 0.33
TPSG1 Q9NRR2 1/20 0.33
FAAH O00519 1/20 0.33
MGLL Q99685 1/20 0.33
ALDH1A1 P00352 2/20 0.32
ALOX15 P16050 1/20 0.32
TSHR P16473 1/20 0.32
HSD17B10 Q99714 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
CNR2 P34972 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5076668 0.93 EPHX1 (0.41) EPHX1CYP2C19MAPTSMN1; SMN2OPRL1
SCHEMBL5073692 0.87 EPHX1 (0.36) EPHX1SMN1; SMN2IDO1
SCHEMBL17754371 0.83 EPHX1 (0.49) EPHX1CYP2C19MAPTSMN1; SMN2IDO1
SCHEMBL8928025 0.77 EPHX1 (0.50) EPHX1CYP2C19MAPTSMN1; SMN2IDO1
SCHEMBL25946385 0.73 EPHX1 (0.50) EPHX1CYP2C19MAPTSMN1; SMN2IDO1
SCHEMBL31512311 0.71 EPHX1 (0.49) EPHX1CYP2C19MAPTSMN1; SMN2IDO1
Hydrochloric Acid SCHEMBL30817611 0.71 EPHX1 (0.49) EPHX1CYP2C19MAPTSMN1; SMN2IDO1
SCHEMBL16312549 0.71 EPHX1 (0.37) EPHX1CYP2C19MAPTFAAHMGLL
SCHEMBL32690599 0.71 KDM4E (0.39) MAPTSMN1; SMN2OPRL1P2RX7ALDH1A1
SCHEMBL21083880 0.71 P2RX7 (0.42) MAPTOPRL1P2RX7ALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1931661-A1 ISOXAZOLO DERIVATIVES AS GABA A ALPHA5 INVERSE AGONISTS F.HOFFMANN-LA ROCHE AG (CH) 2008-06-18 EP disclosed
WO-2007039389-A1 ISOXAZOLO DERIVATIVES AS GABA A ALPHA5 INVERSE AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2007-04-12 WO disclosed