Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | FAAH | O00519 | 3/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16312549 | 0.87 | EPHX1 (0.37) | EPHX1CYP2C19MAPTFAAHMGLL | |
| SCHEMBL5077545 | 0.83 | EPHX1 (0.44) | EPHX1CYP2C19MAPTFAAHMGLL | |
| SCHEMBL16312544 | 0.81 | MAPT (0.38) | EPHX1CYP2C19MAPTMEN1KMT2A | |
| SCHEMBL17684002 | 0.77 | EPHX1 (0.47) | EPHX1SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL8928025 | 0.77 | EPHX1 (0.50) | EPHX1CYP2C19MAPTFAAHMGLL | |
| SCHEMBL5076668 | 0.76 | EPHX1 (0.41) | EPHX1CYP2C19MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7100758 | 0.76 | MAPT (0.41) | MAPTFAAHALDH1A1L3MBTL1CNR2 | |
| SCHEMBL755311 | 0.74 | MAPT (0.39) | MAPTFAAHCYP1A2ALDH1A1L3MBTL1 | |
| SCHEMBL5111553 | 0.73 | HDAC8 (0.47) | EPHX1MAPTTSHRCNR1CNR2 | |
| SCHEMBL1842644 | 0.73 | HDAC8 (0.47) | EPHX1MAPTTSHRCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9636346-B2 | Alpha-oxoacyl amino-caprolactam derivative | SEIKAGAKU CORPORATION (JP) | 2017-05-02 | — | — | US | disclosed |
| US-20160375031-A1 | ALPHA-OXOACYL AMINO-CAPROLACTAM DERIVATIVE | SEIKAGAKU KOGYO CO LTD (JP) | 2016-12-29 | — | — | US | disclosed |
| US-9481707-B2 | α-oxoacyl amino-caprolactam derivative | SEIKAGAKU CORPORATION (JP) | 2016-11-01 | — | — | US | disclosed |
| US-20160137691-A1 | ALPHA-OXOACYL AMINO-CAPROLACTAM DERIVATIVE | SEIKAGAKU CORPORATION (JP) | 2016-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160375031-A1 | ALPHA-OXOACYL AMINO-CAPROLACTAM DERIVATIVE | OGFRL1, ARGLU1, COL1A1 | EPHX1 3306/4885CYP2C19 2361/4885MAPT 4436/4885 |
| US-20160137691-A1 | ALPHA-OXOACYL AMINO-CAPROLACTAM DERIVATIVE | COL2A1, ARGLU1, COL1A1 | EPHX1 3356/4885CYP2C19 1857/4885MAPT 4509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.