Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.43 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL722198 | 0.75 | PDPK1 (0.77) | PDPK1LOXL2CYP2A6ADRB2SMPD3 | |
| SCHEMBL13575353 | 0.72 | PDPK1 (0.48) | PDPK1LOXL2CYP2A6ADRB2SMPD3 | |
| 2-Phenylthiazole SCHEMBL70646 | 0.70 | PDPK1 (1.00) | PDPK1LOXL2CYP2A6ADRB2SMPD3 | |
| SCHEMBL1653986 | 0.70 | PDPK1 (0.68) | PDPK1LOXL2CYP2A6ADRB2SMPD3 | |
| SCHEMBL102331 | 0.69 | PDPK1 (0.59) | PDPK1LOXL2CYP2A6ADRB2SMPD3 | |
| 2-Phenylthiazole SCHEMBL4939218 | 0.68 | PDPK1 (0.95) | PDPK1LOXL2CYP2A6ADRB2SMPD3 | |
| SCHEMBL15805858 | 0.68 | PDPK1 (0.72) | PDPK1LOXL2CYP2A6ADRB2SMPD3 | |
| 2-Phenylthiazole SCHEMBL10519953 | 0.68 | PDPK1 (0.95) | PDPK1LOXL2CYP2A6ADRB2SMPD3 | |
| 2-Phenylthiazole SCHEMBL10667585 | 0.68 | PDPK1 (0.95) | PDPK1LOXL2CYP2A6ADRB2SMPD3 | |
| SCHEMBL17704291 | 0.68 | PDPK1 (0.65) | PDPK1LOXL2CYP2A6ADRB2SMPD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10118934-B2 | Inhibitors of UDP-galactopyranose mutase | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2018-11-06 | — | — | US | disclosed |
| US-20170283437-A1 | Inhibitors of UDP-Galactopyranose Mutase | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2017-10-05 | — | — | US | disclosed |
| US-9708344-B2 | Inhibitors of UDP-galactopyranose mutase | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2017-07-18 | — | — | US | disclosed |
| US-20150344501-A1 | INHIBITORS OF UDP-GALACTOPYRANOSE MUTASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-12-03 | — | — | US | disclosed |
| CN-100474655-C | Organic light-emitting element, method for manufacturing organic light-emitting element, image forming apparatus, and display apparatus | MATSUSHITA ELECTRIC INDUSTRIAL CO LTD (JP) | 2009-04-01 | — | — | CN | disclosed |
| US-7393959-B2 | Di-aryl substituted pyrrole modulators of metabotropic glutamate receptor-5 | MERCK & CO. INC. (US) | 2008-07-01 | — | — | US | disclosed |
| US-7371767-B2 | Heteroaryl substituted pyrrole modulators of metabotropic glutamate receptor-5 | MERCK & CO., INC. (US) | 2008-05-13 | — | — | US | disclosed |
| EP-1613265-A4 | DI-ARYL SUBSTITUTED PYRROLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO INC (US) | 2007-02-14 | — | — | EP | disclosed |
| US-20060193926-A1 | Di-arylsubstituted pyrrole modulators of metabotropic glutamate receptor-5 | MERCK SHARP & DOHME CORP. | 2006-08-31 | — | — | US | disclosed |
| CN-1794990-A | Diaryl substituted pyrrole modulators of metabotropic glutamate receptor-5 | MERCK & CO INC (US) | 2006-06-28 | — | — | CN | disclosed |
| EP-1613265-A2 | DI-ARYL SUBSTITUTED PYRROLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | Merck & Co., Inc. (US) | 2006-01-11 | — | — | EP | disclosed |
| CN-1711804-A | Organic light-emitting element, method for manufacturing organic light-emitting element, image forming apparatus, and display apparatus | MATSUSHITA ELECTRIC INDUSTRIAL CO LTD (JP) | 2005-12-21 | — | — | CN | disclosed |
| US-20050085514-A1 | Heteroaryl substituted pyrrole modulators of metabotropic glutamate receptor-5 | MERCK SHARP & DOHME CORP. | 2005-04-21 | — | — | US | disclosed |
| EP-1458710-A4 | HETEROARYL SUBSTITUTED PYRROLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO INC (US) | 2005-04-20 | — | — | EP | disclosed |
| WO-2004089308-A2 | DI-ARYL SUBSTITUTED PYRROLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO., INC. (US) | 2004-10-21 | — | — | WO | disclosed |
| EP-1458710-A1 | HETEROARYL SUBSTITUTED PYRROLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | Merck & Co., Inc. (US) | 2004-09-22 | — | — | EP | disclosed |
| WO-2004030637-A2 | TREATMENT OF OBESITY AND OTHER DISORDERS ASSOCIATED WITH EXCESSIVE FOOD INTAKE | MERCK & CO., INC. (US) | 2004-04-15 | — | — | WO | disclosed |
| WO-2003059904-A1 | HETEROARYL SUBSTITUTED PYRROLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO., INC. (US) | 2003-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170283437-A1 | Inhibitors of UDP-Galactopyranose Mutase | UGDH, GALE, UGGT1 | PDPK1 1204/4885LOXL2 1573/4885CYP2A6 2830/4885 |
| US-20150344501-A1 | INHIBITORS OF UDP-GALACTOPYRANOSE MUTASE | UGDH, GALE, UGGT1 | PDPK1 1204/4885LOXL2 1573/4885CYP2A6 2830/4885 |
| US-20050085514-A1 | Heteroaryl substituted pyrrole modulators of metabotropic glutamate receptor-5 | GRM5, GRIK5, GRIN2C | PDPK1 1058/4885LOXL2 3862/4885CYP2A6 2345/4885 |
| US-10118934-B2 | Inhibitors of UDP-galactopyranose mutase | UGDH, GALE, UGGT1 | PDPK1 1204/4885LOXL2 1573/4885CYP2A6 2830/4885 |
| US-20060193926-A1 | Di-arylsubstituted pyrrole modulators of metabotropic glutamate receptor-5 | GRM5, GRIK5, GRIN2B | PDPK1 922/4885LOXL2 4023/4885CYP2A6 1537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.