SCHEMBL5078593

SCHEMBL5078593

C[Si](C)(Cc1ccccc1)OCC1(CO[Si](C)(C)Cc2ccccc2)c2ccccc2-c2ccccc21

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APEX1 P27695 1/20 0.37
KMT2A Q03164 1/20 0.35
KCNQ2 O43526 4/20 0.34
CYP3A4 P08684 2/20 0.34
ALOX15 P16050 2/20 0.34
TSHR P16473 2/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2C9 P11712 1/20 0.34
ALDH1A1 P00352 2/20 0.33
MAPT P10636 1/20 0.33
ITGA4 P13612 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.31
PDK2 Q15119 2/20 0.31
PPARG P37231 1/20 0.31
PPARA Q07869 1/20 0.31
ADRA1D P25100 1/20 0.30
ADRA1A P35348 1/20 0.30
ADRA1B P35368 1/20 0.30
KCNH2 Q12809 1/20 0.30
THRB P10828 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5078691 0.94 APEX1 (0.33) APEX1KMT2AKCNQ2CYP3A4ALOX15
SCHEMBL5081808 0.92 SMN1; SMN2 (0.33) APEX1KMT2AKCNQ2CYP3A4ALOX15
SCHEMBL5082331 0.89 CYP2C9 (0.32) APEX1KMT2ACYP2C9PDK2TDP1
SCHEMBL5084662 0.88 PDK2 (0.39) KCNQ2CYP3A4ALOX15TSHRPDK2
SCHEMBL5082316 0.84 APEX1 (0.35) APEX1KMT2AKCNQ2CYP3A4ALOX15
SCHEMBL5078647 0.81 APEX1 (0.36) APEX1KMT2AKCNQ2CYP3A4ALOX15
SCHEMBL6874556 0.80 ALDH1A1 (0.33) APEX1KCNQ2CYP3A4ALOX15TSHR
SCHEMBL5082343 0.79 APEX1 (0.39) APEX1KMT2AKCNQ2CYP3A4ALOX15
SCHEMBL5078725 0.79 APEX1 (0.34) APEX1KMT2AKCNQ2CYP3A4ALOX15
SCHEMBL5085328 0.78 ALDH1A1 (0.33) APEX1ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060142146-A1 Catalyst for olefin polymerization and use of the same CHINA PETROLEUM & CHEMICAL CORPORATION 2006-06-29 US claimed
US-7323431-B2 Catalyst for olefin polymerization and use of the same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2008-01-29 US disclosed
US-20060142146-A1 Catalyst for olefin polymerization and use of the same CHINA PETROLEUM & CHEMICAL CORPORATION 2006-06-29 US disclosed