SCHEMBL5081808

SCHEMBL5081808

CCOCC1(CO[Si](C)(C)Cc2ccccc2)c2ccccc2-c2ccccc21

nearest known ligand 0.33

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.33
APEX1 P27695 1/20 0.32
ALDH1A1 P00352 1/20 0.31
KMT2A Q03164 1/20 0.31
KCNQ2 O43526 1/20 0.30
CYP1A2 P05177 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2C9 P11712 1/20 0.30
ALOX15 P16050 1/20 0.30
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5078593 0.92 APEX1 (0.37) SMN1; SMN2APEX1ALDH1A1KMT2AKCNQ2
SCHEMBL5082331 0.90 CYP2C9 (0.32) APEX1KMT2ACYP2C9
SCHEMBL5085328 0.87 ALDH1A1 (0.33) SMN1; SMN2APEX1ALDH1A1
SCHEMBL5078691 0.86 APEX1 (0.33) APEX1ALDH1A1KMT2AKCNQ2CYP1A2
SCHEMBL5082314 0.86 SMN1; SMN2 (0.33) SMN1; SMN2APEX1ALDH1A1KMT2ACYP1A2
SCHEMBL5082365 0.83 SMN1; SMN2 (0.31) SMN1; SMN2APEX1ALDH1A1KMT2ACYP1A2
SCHEMBL5078695 0.83 SMN1; SMN2 (0.34) SMN1; SMN2APEX1KMT2AKCNQ2CYP1A2
SCHEMBL5078657 0.81 CYP2C9 (0.33) SMN1; SMN2KMT2ACYP2C9
SCHEMBL5082359 0.81 SMN1; SMN2 (0.34) SMN1; SMN2APEX1KMT2ACYP1A2
SCHEMBL5084662 0.81 PDK2 (0.39) KCNQ2CYP3A4ALOX15TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060142146-A1 Catalyst for olefin polymerization and use of the same CHINA PETROLEUM & CHEMICAL CORPORATION 2006-06-29 US claimed
US-7323431-B2 Catalyst for olefin polymerization and use of the same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2008-01-29 US disclosed
US-20060142146-A1 Catalyst for olefin polymerization and use of the same CHINA PETROLEUM & CHEMICAL CORPORATION 2006-06-29 US disclosed