Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.40 |
| ▸ | SRC | P12931 | 15/20 | 0.40 |
| ▸ | PRKDC | P78527 | 14/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.40 |
| ▸ | ABL1 | P00519 | 11/20 | 0.40 |
| ▸ | EGFR | P00533 | 9/20 | 0.40 |
| ▸ | HCK | P08631 | 9/20 | 0.40 |
| ▸ | KDR | P35968 | 9/20 | 0.40 |
| ▸ | MTOR | P42345 | 9/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 9/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | STK16 | O75716 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL402040 | 0.82 | PIK3CD (0.61) | PIK3CDSRCPRKDCPIK3CAPIK3CB | |
| SCHEMBL402191 | 0.78 | PIK3CD (0.51) | PIK3CDSRCPRKDCPIK3CAPIK3CB | |
| SCHEMBL399768 | 0.78 | PIK3CD (0.51) | PIK3CDSRCPRKDCPIK3CAPIK3CB | |
| SCHEMBL402041 | 0.77 | SRC (0.43) | PIK3CDSRCPRKDCPIK3CAPIK3CB | |
| SCHEMBL400100 | 0.77 | KDR (0.50) | PIK3CDSRCPRKDCPIK3CAPIK3CB | |
| SCHEMBL5316615 | 0.77 | KDR (0.50) | PIK3CDSRCPRKDCPIK3CAPIK3CB | |
| Carbamic Acid SCHEMBL19244770 | 0.77 | PIK3CD (0.58) | PIK3CDSRCPRKDCPIK3CAPIK3CB | |
| SCHEMBL19244961 | 0.76 | KDR (0.55) | PIK3CDSRCPRKDCPIK3CAPIK3CB | |
| SCHEMBL5179813 | 0.75 | PIK3CD (0.46) | PIK3CDSRCPRKDCPIK3CAPIK3CB | |
| SCHEMBL398358 | 0.75 | PIK3CD (0.46) | PIK3CDSRCPRKDCPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080014200-A1 | Combined treatment with 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents | OSI PHARMACEUTICALS, INC. | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080014200-A1 | Combined treatment with 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents | IGF1R, IGFBP6, CDK6 | PIK3CD 312/4885SRC 292/4885PRKDC 460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.