Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | DHFR | P00374 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | PNP | P00491 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5073660 | 0.92 | TLR8 (0.41) | TLR8TLR7DHFRPNP | |
| SCHEMBL5078769 | 0.80 | MPO (0.40) | DHFRMPO | |
| SCHEMBL5075205 | 0.79 | TLR8 (0.43) | TLR8TLR7DHFRMPO | |
| SCHEMBL5079686 | 0.75 | DHFR (0.35) | TLR8DHFR | |
| SCHEMBL5073662 | 0.70 | DHFR (0.38) | TLR8TLR7DHFRMPOPNP | |
| SCHEMBL8722636 | 0.68 | DHFR (0.42) | TLR8TLR7DHFRMPOPNP | |
| SCHEMBL18593906 | 0.67 | TLR8 (0.68) | TLR8TLR7 | |
| SCHEMBL18587114 | 0.65 | TLR8 (0.46) | TLR8TLR7DHFR | |
| SCHEMBL6272241 | 0.64 | TLR8 (0.48) | TLR8DHFR | |
| SCHEMBL4390007 | 0.64 | PRMT5 (0.41) | TLR8TLR7DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948173-A2 | HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS | Coley Pharmaceutical Group, Inc. (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007056112-A2 | HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2007-05-18 | — | — | WO | disclosed |