Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 16/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5080691 | 0.90 | IGF1R (0.36) | IGF1RCYP3A4CYP2C9TNK2 | |
| SCHEMBL5080228 | 0.85 | TNK2 (0.41) | TNK2 | |
| SCHEMBL4762466 | 0.80 | IGF1R (0.36) | IGF1RCYP2C9TNK2 | |
| SCHEMBL5079147 | 0.72 | IGF1R (0.48) | IGF1RCYP3A4TNK2 | |
| SCHEMBL4070971 | 0.70 | IGF1R (0.45) | IGF1RCYP3A4TNK2 | |
| SCHEMBL4070968 | 0.70 | IGF1R (0.45) | IGF1RCYP3A4TNK2 | |
| SCHEMBL4724211 | 0.70 | IGF1R (0.33) | IGF1R | |
| SCHEMBL402609 | 0.70 | IGF1R (0.82) | IGF1RCYP3A4CYP2C9TNK2 | |
| SCHEMBL5083358 | 0.67 | IGF1R (0.58) | IGF1RCYP3A4TNK2 | |
| SCHEMBL5083550 | 0.66 | IGF1R (0.40) | IGF1RCYP3A4TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979002-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007075554-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |