Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 11/20 | 0.34 |
| ▸ | MERTK | Q12866 | 8/20 | 0.34 |
| ▸ | AXL | P30530 | 4/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312412 | 0.95 | TYRO3 (0.39) | TYRO3MERTKAXL | |
| SCHEMBL14312797 | 0.94 | ACVRL1 (0.35) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL14312700 | 0.94 | TYRO3 (0.40) | TYRO3MERTKAXL | |
| SCHEMBL14531349 | 0.93 | TYRO3 (0.36) | TYRO3MERTKAXL | |
| SCHEMBL14312882 | 0.92 | TYRO3 (0.37) | TYRO3MERTKAXL | |
| SCHEMBL14313165 | 0.91 | SRC (0.38) | TYRO3MERTKAXLRIPK1 | |
| SCHEMBL14313229 | 0.91 | ACVRL1 (0.36) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL14312752 | 0.90 | INSR (0.39) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL14531707 | 0.89 | TYRO3 (0.39) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL14313121 | 0.89 | TYRO3 (0.42) | ACVRL1TYRO3MERTKAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945222-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | Bayer HealthCare AG (DE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007056170-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | BAYER HEALTHCARE AG (DE) | 2007-05-18 | — | — | WO | disclosed |