SCHEMBL5081727

SCHEMBL5081727

Nc1cc(/N=C/c2ccccc2)c(N)cc1/N=C/c1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.53
MEN1 O00255 2/20 0.53
KMT2A Q03164 2/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
RAB9A P51151 2/20 0.53
POLB P06746 1/20 0.53
HTT P42858 1/20 0.53
BLM P54132 1/20 0.53
KDM4E B2RXH2 4/20 0.50
ALDH1A1 P00352 3/20 0.50
LMNA P02545 2/20 0.50
HPGD P15428 2/20 0.50
LIG1 P18858 2/20 0.49
CA1 P00915 4/20 0.47
CA2 P00918 4/20 0.47
CA12 O43570 3/20 0.47
CA9 Q16790 3/20 0.47
L3MBTL1 Q9Y468 1/20 0.46
G6PD P11413 1/20 0.42
PTGS2 P35354 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5081728 1.00 MAPT (0.53) MAPTMEN1KMT2ASMN1; SMN2RAB9A
SCHEMBL5085334 0.94 MAPT (0.51) MAPTMEN1KMT2ASMN1; SMN2RAB9A
SCHEMBL5085338 0.94 MAPT (0.51) MAPTMEN1KMT2ASMN1; SMN2RAB9A
SCHEMBL5482713 0.84 MAPT (0.47) MAPTMEN1KMT2ASMN1; SMN2RAB9A
SCHEMBL5482714 0.84 MAPT (0.47) MAPTMEN1KMT2ASMN1; SMN2RAB9A
SCHEMBL28599218 0.83 KDM4E (0.55) MAPTMEN1KMT2ASMN1; SMN2RAB9A
SCHEMBL17973873 0.83 KDM4E (0.55) MAPTMEN1KMT2ASMN1; SMN2RAB9A
SCHEMBL5470892 0.82 MAPT (0.43) MAPTMEN1KMT2ASMN1; SMN2RAB9A
SCHEMBL5470889 0.82 MAPT (0.43) MAPTMEN1KMT2ASMN1; SMN2RAB9A
SCHEMBL14524455 0.81 LMNA (0.55) MAPTMEN1KMT2ASMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1462471-B1 Dielectric films and materials therefor DAICEL CHEM (JP) 2008-07-30 EP disclosed
US-20070078256-A1 Prepolymers, prepolymer compositions, high-molecular-weight polymers with pore structure, and dielectric films DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2007-04-05 US disclosed
US-7186454-B2 Dielectric films and materials therefor DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2007-03-06 US disclosed
US-20070032556-A1 Aromatic polyamine derivative DAICEL CHEMICAL INSUSTRIES, LTD. (JP) 2007-02-08 US disclosed
EP-1683822-A1 PREPOLYMER, PREPOLYMER COMPOSITION, HIGH MOLECULAR WEIGHT POLYMER HAVING STRUCTURE CONTAINING HOLE AND ELECTRICALLY INSULATING FILM Daicel Chemical Industries, Ltd. (JP) 2006-07-26 EP disclosed
EP-1681284-A1 AROMATIC POLYAMINE DERIVATIVE Daicel Chemical Industries, Ltd. (JP) 2006-07-19 EP disclosed
EP-1462471-A1 Dielectric films and materials thereof Daicel Chemical Industries, Ltd. (JP) 2004-09-29 EP disclosed
US-20040175858-A1 Dielectric films and materials therefor DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2004-09-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070032556-A1 Aromatic polyamine derivative SRM, PRMT1, KDM8 MAPT 3786/4885MEN1 1236/4885KMT2A 243/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.