⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735133 | 0.80 | — | — | |
| SCHEMBL317175 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL7249488 | 0.78 | — | — | |
| Propene SCHEMBL28208916 | 0.78 | ALDH1A1 (0.41) | — | |
| SCHEMBL6404617 | 0.78 | ALDH1A1 (0.43) | — | |
| SCHEMBL6158862 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL28362750 | 0.77 | NPC1 (0.42) | — | |
| SCHEMBL218446 | 0.75 | — | — | |
| SCHEMBL562917 | 0.74 | — | — | |
| SCHEMBL25368 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2743 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024022481-A1 | PHENYL-SUBSTITUTED DIHYDRONAPHTHYRIDINE COMPOUNDS, AND PREPARATION AND USE THEREOF | 苏中药业集团股份有限公司 | 2024-02-01 | — | — | WO | claimed |
| WO-2023225661-A1 | MACROCYCLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-11-23 | — | — | WO | claimed |
| EP-4217358-A1 | INDAZOLES AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS AND METHODS OF USING SAME | 1st Biotherapeutics, Inc. (KR) | 2023-08-02 | — | — | EP | claimed |
| US-20230192631-A1 | Biphenyl Derivatives | HOFFMANN-LA ROCHE INC. (US) | 2023-06-22 | — | — | US | claimed |
| US-11649255-B2 | Indazoles as hematopoietic progenitor kinase 1 (HPK1) inhibitors and methods using same | 1ST Biotherapeutics, Inc. (KR) | 2023-05-16 | — | — | US | claimed |
| CN-115397813-A | Biphenyl derivatives | 豪夫迈·罗氏有限公司 | 2022-11-25 | — | — | CN | claimed |
| CN-114599653-A | Indazoles as inhibitors of hematopoietic progenitor kinase 1(HPK1) and methods of use thereof | 第一生物治疗股份有限公司 | 2022-06-07 | — | — | CN | claimed |
| CN-114599651-A | Indazoles as inhibitors of hematopoietic progenitor kinase 1(HPK1) and methods of use thereof | 第一生物治疗股份有限公司 | 2022-06-07 | — | — | CN | claimed |
| WO-2022064459-A1 | INDAZOLES AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS AND METHODS OF USING SAME | 1ST Biotherapeutics, Inc. (KR) | 2022-03-31 | — | — | WO | claimed |
| US-20220098219-A1 | INDAZOLES AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS AND METHODS USING SAME | 1ST Biotherapeutics, Inc. | 2022-03-31 | — | — | US | claimed |
| US-5064842-A | Thromboxane Synthetase Inhibitors | JOHN WYETH & BROTHER LIMITED (GB) | 1991-11-12 | — | — | US | claimed |
| US-H972-H | Direct positive color photographic materials | FUJI PHOTO FILM CO., LTD. (JP) | 1991-10-01 | — | — | US | claimed |
| EP-0172029-B1 | 1,4-DIHYDROPYRIDINES | JOHN WYETH & BROTHER LIMITED (GB) | 1991-02-27 | — | — | EP | claimed |
| US-4966833-A | USING HETEROCYCLIC NITROGEN CONTAINING COMPOUND | FUJI PHOTO FILM CO., LTD. (JP) | 1990-10-30 | — | — | US | claimed |
| US-4895939-A | ANTIBIOTICS | BRISTOL-MYERS COMPANY (US) | 1990-01-23 | — | — | US | claimed |
| US-4772683-A | SILYLATION, AZETIDONE THIOLESTERS | BRISTOL-MYERS COMPANY (US) | 1988-09-20 | — | — | US | claimed |
| EP-0233015-A2 | 1,4-Dihydropyridines | JOHN WYETH & BROTHER LIMITED (GB) | 1987-08-19 | — | — | EP | claimed |
| EP-0172029-A1 | 1,4-Dihydropyridines | JOHN WYETH & BROTHER LIMITED (GB) | 1986-02-19 | — | — | EP | claimed |
| US-4192879-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-03-11 | — | — | US | claimed |
| US-4166856-A | Thiazole and isothiazole derivative as blockers of histamine H2 -receptors | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-09-04 | — | — | US | claimed |