Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 4/20 | 0.37 |
| ▸ | NQO1 | P15559 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.36 |
| ▸ | TOP2A | P11388 | 2/20 | 0.36 |
| ▸ | NSD2 | O96028 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29369288 | 0.92 | IDO1 (0.37) | IDO1NQO2NQO1MEN1USP2 | |
| SCHEMBL105984 | 0.92 | IDO1 (0.37) | IDO1NQO2NQO1MEN1USP2 | |
| Hydrochloric Acid SCHEMBL1650422 | 0.91 | NQO2 (0.36) | IDO1NQO2NQO1MEN1USP2 | |
| SCHEMBL8543978 | 0.86 | IDO1 (0.35) | IDO1NQO2NQO1MEN1USP2 | |
| SCHEMBL8542166 | 0.84 | MEN1 (0.44) | NQO2NQO1MEN1USP2LMNA | |
| SCHEMBL8545959 | 0.83 | NQO2 (0.38) | IDO1NQO2NQO1MEN1USP2 | |
| SCHEMBL8546191 | 0.83 | IDO1 (0.37) | IDO1NQO2NQO1 | |
| SCHEMBL8543922 | 0.82 | MEN1 (0.37) | NQO2NQO1MEN1USP2LMNA | |
| SCHEMBL8543902 | 0.79 | IDO1 (0.35) | IDO1NQO2NQO1 | |
| SCHEMBL8547450 | 0.78 | NQO1 (0.43) | NQO2NQO1PAX8SMARCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11337978-B2 | Stable lyophilisates comprising 5,10-methylene-(6R)-tetrahydrofolic acid | MERCK PATENT GMBH (DE) | 2022-05-24 | — | — | US | disclosed |
| EP-3668516-B1 | STABLE LYOPHILISATES COMPRISING 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID AND A DICARBOXYLIC ACID | MERCK PATENT GMBH (DE) | 2021-09-22 | — | — | EP | disclosed |
| US-20200368236-A1 | Stable lyophilisates comprising 5,10-methylene-(6R)-tetrahydrofolic acid | MERCK PATENT GMBH (DE) | 2020-11-26 | — | — | US | disclosed |
| EP-2934535-A2 | SUBSTITUTED PYRROLOPYRIMIDINES AS HDM2 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-10-28 | — | — | EP | disclosed |
| WO-2014100071-A2 | SUBSTITUTED PYRROLOPYRIMIDINES AS HDM2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-06-26 | — | — | WO | disclosed |
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| EP-1891089-A2 | HCV PROTEASE INHIBITORS IN COMBINATION WITH FOOD | SCHERING CORPORATION (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006130686-A2 | HCV PROTEASE INHIBITORS IN COMBINATION WITH FOOD | SCHERING CORPORATION (US) | 2006-12-07 | — | — | WO | disclosed |