Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.65 |
| ▸ | RARB | P10826 | 1/20 | 0.59 |
| ▸ | RARG | P13631 | 1/20 | 0.59 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.56 |
| ▸ | RXRA | P19793 | 3/20 | 0.54 |
| ▸ | RXRB | P28702 | 3/20 | 0.54 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | RXRG | P48443 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4578224 | 0.89 | SRD5A2 (0.65) | SRD5A2RARBRARGNR1H4EPHX2 | |
| SCHEMBL569727 | 0.89 | SRD5A2 (0.65) | SRD5A2RARBRARGNR1H4EPHX2 | |
| SCHEMBL26986837 | 0.88 | SRD5A2 (0.62) | SRD5A2RARBRARGNR1H4EPHX2 | |
| Terephthalic Acid SCHEMBL28791012 | 0.87 | TSHR (0.57) | SRD5A2CA1CA2TDP1MAPT | |
| Terephthalic Acid SCHEMBL10938231 | 0.87 | TSHR (0.57) | SRD5A2CA1CA2TDP1MAPT | |
| Terephthalic Acid SCHEMBL855281 | 0.87 | TSHR (0.57) | SRD5A2CA1CA2TDP1MAPT | |
| Lactic Acid SCHEMBL8967228 | 0.85 | SRD5A2 (0.69) | SRD5A2RARBRARGNR1H4EPHX2 | |
| Ethylene Glycol SCHEMBL21074269 | 0.85 | SRD5A2 (0.74) | SRD5A2RARBRARGNR1H4EPHX2 | |
| SCHEMBL36693 | 0.84 | SRD5A2 (0.87) | SRD5A2RARBRARGNR1H4EPHX2 | |
| SCHEMBL1072692 | 0.84 | SRD5A2 (0.54) | SRD5A2RARBRARGNR1H4EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1666505-B1 | CATALYST COMPONENTS CATALYSTS FOR OLEFINIC POLYMERIZATION AND THE USE THEREOF | CHINA PETROLEUM & CHEMICAL (CN) | 2016-03-23 | — | — | EP | disclosed |
| US-7332455-B2 | Catalyst component and catalyst for olefin polymerization as well as use thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2008-02-19 | — | — | US | disclosed |
| EP-1666505-A1 | CATALYST COMPONENTS CATALYSTS FOR OLEFINIC POLYMERIZATION AND THE USE THEREOF | China Petroleum & Chemical Corporation (CN) | 2006-06-07 | — | — | EP | disclosed |
| US-20050119427-A1 | Catalyst component and catalyst for olefin polymerization as well as use thereof | BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2005-06-02 | — | — | US | disclosed |