Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA3 | P07451 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL855281 | 1.00 | TSHR (0.57) | TSHRTP53ALDH1A1SMN1; SMN2KMT2A | |
| Terephthalic Acid SCHEMBL10938231 | 1.00 | TSHR (0.57) | TSHRTP53ALDH1A1SMN1; SMN2KMT2A | |
| Terephthalic Acid SCHEMBL11809850 | 0.96 | TSHR (0.52) | TSHRTP53ALDH1A1SMN1; SMN2KMT2A | |
| Terephthalic Acid SCHEMBL29132843 | 0.96 | TSHR (0.52) | TSHRTP53ALDH1A1SMN1; SMN2KMT2A | |
| Terephthalic Acid SCHEMBL27843678 | 0.96 | TSHR (0.52) | TSHRTP53ALDH1A1SMN1; SMN2KMT2A | |
| Terephthalic Acid SCHEMBL28992746 | 0.92 | USP5 (0.50) | TSHRTP53ALDH1A1SMN1; SMN2KMT2A | |
| Paraben SCHEMBL4616664 | 0.92 | CA2 (0.64) | TSHRTP53ALDH1A1SMN1; SMN2KMT2A | |
| 4-Methylbenzoic Acid SCHEMBL5081494 | 0.92 | ALDH1A1 (0.68) | TSHRTP53ALDH1A1SMN1; SMN2KMT2A | |
| Benzoic Acid SCHEMBL524377 | 0.91 | TSHR (0.61) | TSHRTP53ALDH1A1SMN1; SMN2KMT2A | |
| Benzoic Acid SCHEMBL1255194 | 0.91 | TSHR (0.61) | TSHRTP53ALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101921384-B | Preparation method of ethylene terephthalate 1, 2-propylene glycol copolyester | PETROCHINA CO LTD | 2012-05-30 | — | — | CN | disclosed |
| CN-101921384-A | Preparation method of ethylene terephthalate 1, 2-propylene glycol copolyester | PETROCHINA CO LTD | 2010-12-22 | — | — | CN | disclosed |