Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.84 |
| ▸ | PLK4 | O00444 | 2/20 | 0.74 |
| ▸ | PLK1 | P53350 | 2/20 | 0.74 |
| ▸ | RAF1 | P04049 | 2/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.59 |
| ▸ | EGFR | P00533 | 3/20 | 0.59 |
| ▸ | IGF1R | P08069 | 2/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.59 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.57 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.57 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | GMNN | O75496 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5082716 | 1.00 | DHFR (0.84) | DHFRPLK4PLK1RAF1ERBB2 | |
| SCHEMBL4727806 | 0.88 | RAF1 (0.73) | DHFRPLK4PLK1RAF1ERBB2 | |
| SCHEMBL5082831 | 0.88 | RAF1 (0.73) | DHFRPLK4PLK1RAF1ERBB2 | |
| SCHEMBL1394626 | 0.87 | PLK4 (0.80) | DHFRPLK4PLK1RAF1ERBB2 | |
| SCHEMBL1394624 | 0.87 | PLK4 (0.80) | DHFRPLK4PLK1RAF1ERBB2 | |
| SCHEMBL7979216 | 0.86 | DHFR (0.84) | DHFRPLK4PLK1RAF1ERBB2 | |
| SCHEMBL1395380 | 0.86 | DHFR (0.84) | DHFRPLK4PLK1RAF1ERBB2 | |
| SCHEMBL7979219 | 0.86 | DHFR (0.84) | DHFRPLK4PLK1RAF1ERBB2 | |
| SCHEMBL1395377 | 0.86 | DHFR (0.84) | DHFRPLK4PLK1RAF1ERBB2 | |
| SCHEMBL7979353 | 0.85 | PLK4 (1.00) | DHFRPLK4PLK1RAF1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080044390-A1 | Methods and compositions for the treatment of neurodegenerative disorders | CHDI, INCORPORATED | 2008-02-21 | — | — | US | disclosed |
| US-6268391-B1 | Benzylidene-1,3-dihydro-indol-2-one derivatives a receptor tyrosine kinase inhibitors, particularly of Raf kinases | GLAXO WELLCOME INC. | 2001-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080044390-A1 | Methods and compositions for the treatment of neurodegenerative disorders | HTT, SNCA, NLN | DHFR 1017/4885PLK4 3482/4885PLK1 2516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.