Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 4/20 | 1.00 |
| ▸ | PLK1 | P53350 | 1/20 | 1.00 |
| ▸ | DHFR | P00374 | 1/20 | 0.61 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.60 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.58 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.56 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.56 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.56 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.56 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.56 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.56 |
| ▸ | RAF1 | P04049 | 2/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979350 | 1.00 | PLK4 (1.00) | PLK4PLK1DHFRMAP1LC3BLRRK2 | |
| SCHEMBL1395360 | 0.89 | PLK4 (0.80) | PLK4PLK1DHFRMAP1LC3BLRRK2 | |
| SCHEMBL1395363 | 0.89 | PLK4 (0.80) | PLK4PLK1DHFRMAP1LC3BLRRK2 | |
| SCHEMBL1394626 | 0.89 | PLK4 (0.80) | PLK4PLK1DHFRLRRK2PSEN1 | |
| SCHEMBL1394624 | 0.89 | PLK4 (0.80) | PLK4PLK1DHFRLRRK2PSEN1 | |
| SCHEMBL30578769 | 0.89 | PLK4 (0.80) | PLK4PLK1DHFRMAP1LC3BLRRK2 | |
| SCHEMBL1395087 | 0.89 | PLK4 (0.79) | PLK4PLK1MAP1LC3BLRRK2PSEN1 | |
| SCHEMBL1395085 | 0.89 | PLK4 (0.79) | PLK4PLK1MAP1LC3BLRRK2PSEN1 | |
| SCHEMBL5082716 | 0.85 | DHFR (0.84) | PLK4PLK1DHFRRAF1KMT2A | |
| SCHEMBL5082711 | 0.85 | DHFR (0.84) | PLK4PLK1DHFRRAF1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268391-B1 | Benzylidene-1,3-dihydro-indol-2-one derivatives a receptor tyrosine kinase inhibitors, particularly of Raf kinases | GLAXO WELLCOME INC. | 2001-07-31 | — | — | US | disclosed |